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International Journal of Pharmacology

Year: 2011 | Volume: 7 | Issue: 5 | Page No.: 589-598
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Authors

Ravi A. Manek

Navin R. Sheth

Jitendra D. Vaghasiya

Shailesh V. Malaviya

Nurudin P. Jivani

J R. Chavda

Keywords

Synergistic interactions between the components of mixtures of herb are a vital part of their therapeutic efficacy. There is no real basis for better efficacy of a mixture of herb extract than an equivalent dose of an individual herbal extract. Speculation as to explain this, whether it involves synergy, enhanced bioavailability, cumulative effects or simply the additive properties of the constituents requires further research. Liquorice, Kantkari and Vasaka are present in number of herbal formulation available in market for asthma and respiratory disorders so, present study was undertaken to explore the interaction potential of Glycyrrhiza glabra with Solanum xanthocarpum and Adhatoda vasica on mast cell stabilization compound 48/80 and egg albumin induced degranulation. Isobole method and Combination Index values were used to derive possible magnitude of interaction at various combinations. Compound 48/80 and egg albumin significantly disrupted mast cells (p<0.001). Pretreatment of mast cell with Liquorice Extract (LE), Solanum xanthocarpum Extract (SXE) and Adhatoda vasica Extract (AVE) showed significant protection (p<0.05) against Compound 48/80 and egg albumin induced degranulation. This activity of all the extracts was found to be dose dependant. Mast cell treated with various combinations of Adhatoda vasica extract and Liquorice extract (AVE+LE) as well as Solanum xanthocarpum extract and Liquorice extract (SXE+LE), demonstrated significant (p<0.001) stabilization against compound 48/80 and egg albumin induced mast cell degranulation. The isobologram and combination index analysis suggested that combination of LE with SXE and AVE has synergistic effects (and may be nearly additive at some effect level) on mast cell stabilization against compound 48/80 as well as egg albumin degranulation. Thus, it appeared to have substantial activity in this in vitro study, a combination of Liquorice extract with Solanum xanthocarpum extract and Adhatoda vasica extract deserves further clinical investigation in properly designed clinical trials in patients with allergic conditions.
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How to cite this article

Ravi A. Manek, Navin R. Sheth, Jitendra D. Vaghasiya, Shailesh V. Malaviya, Nurudin P. Jivani and J R. Chavda, 2011. Study on Herb-herb Interaction Potential of Glycyrrhiza glabra with Solanum xanthocarpum and Adhatoda vasica on Mast Cell Stabilizing Activity. International Journal of Pharmacology, 7: 589-598.

DOI: 10.3923/ijp.2011.589.598

URL: https://scialert.net/abstract/?doi=ijp.2011.589.598

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