Submit Manuscript

Research Journal of Environmental Toxicology

Year: 2010 | Volume: 4 | Issue: 4 | Page No.: 205-213
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 763

Search

Authors

A.C.C. Egbuonu

L.U.S. Ezeanyika

P.M. Ejikeme

O. Obidoa

Keywords

Research Article

Histomorphologic Alterations in the Liver of Male Wistar Rats Treated with L-Arginine Glutamate and Monosodium Glutamate

A.C.C. Egbuonu, L.U.S. Ezeanyika, P.M. Ejikeme and O. Obidoa
Adult male Wistar rats were fed with arginine (ARG) (60 mg kg¯1 b.wt.), glutamate (GLU) (90 mg kg¯1 b.wt.), monosodium glutamate (MSG) (15 mg kg¯1 b.wt.), ARG+GLU (60:90 mg kg¯1 b.wt.) or ARG+MSG (60:15 mg kg¯1 b.wt.). The feeding was by oral intubation and was daily for 28 days. The aim was to investigate possible alterations in the serum biochemistry and liver histology induced by ARG, GLU or MSG either alone or in such combinations as ARG+GLU or ARG+MSG. After 28 days oral treatment, rats treated with ARG, GLU or MSG alone significantly (p<0.05) increased the serum alkaline aminotransferase (ALT) activity, whereas rats co-treated with ARG and either GLU or MSG decreased (p<0.05) the serum ALT activity. In comparison with the control, the other treatment groups elicited a significant quantitative increase in the serum aspartate aminotransferase (AST) activity and the computed AST:ALT ratio but, the observed increase in the ARG-treated group was consistently lower relative to the other groups. Liver sections of rats from the various treatment groups showed varying degrees of focally diffuse (random) hepatocellular necrosis. On the whole, the study suggests that sub-acute daily oral treatment of male Wistar rats with ARG, GLU or MSG alone or ARG together with GLU or MSG could possibly impair their physiological functions as evidenced in the significant alterations in the serum biochemistry and liver histology of this study. The results are considerably significant going by the possible inadvertent abuse of ARG, GLU and MSG alone or together in diets and drugs.
PDF Fulltext XML References Citation

Related Articles

Artemether-lumefantrine Improved Superoxide Dismutase Co-regulation Related Antioxidant Defense in Monosodium Glutamate-induced Oxidative Stress in Rats
Artemether-lumefantrine Improved Superoxide Dismutase Co-regulation Related Antioxidant Defense in Monosodium Glutamate-induced Oxidative Stress in Rats
Quality Assessment of Waterside River, Ogbor Hill Aba 3: Effect of Three-Point Samples on Kidney Histo-architecture and Some Seric Bio-functional Indicators of Wistar Rats
Dysfunctional Liver and other High Metabolic Organs in Asymptomatic Petroleum Depot Workers in Calabar South-South, Nigeria
Cardiovascular Risks and Impaired Lipid Metabolism in Asymptomatic Petroleum Depot Workers in Calabar Metropolis, Nigeria
Neuroprotective Evaluation of Extract of Ginger (Zingiber officinale) Root in Monosodium Glutamate-Induced Toxicity in Defferent Brain Areas Male Albino Rats
Some Biochemical Effects of Sub-Acute Oral Administration of L-Arginine on Monosodium Glutamate-Fed Wistar Albino Rats 2: Serum Alkaline Phosphatase, Total Acid Phosphatase and Aspartate Aminotransferase Activities
Nitric Oxide: Role in Biological System
Low Dose of L-Arginine Does Not Change Endothelial Permeability of Aorta and Coronary Arteries in Rat
The Combined Effects of Excessive Consumption of Ginger, Clove, Red Pepper and Black Pepper on the Histology of the Liver

Leave a Comment

Your email address will not be published. Required fields are marked *