Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 11 | Page No.: 627-633
DOI: 10.3923/pjbs.2011.627.633
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Nephrotoxicity and Oxidative Stress of Single Large Dose or Two Divided Doses of Gentamicin in Rats
Mahmoud Kandeel, Iman Abdelaziz, Nagwan Elhabashy, Hanaa Hegazy and Yasmin Tolba

Abstract:
Gentamicin (GS) is a potent antimicrobial exhibiting concentration dependent bacterial killing. A high dose of gentamicin (10 mg kg-1) is required to reach sufficient concentrations in specific fluids as cerebrospinal fluid and to be effective on antibiotics resistant bacteria as well as treatment of acute and dangerous illness. Using a rat model, the renal toxicity and oxidative stress of administering gentamicin (10 mg kg-1 daily for 7 days) either in a single dose or divided into 2 doses was investigated. The safety of dose regimens was assessed through oxidant-antioxidant parameters as well as renal function tests. Typical renal damage and high oxidative stress were evident in the control group receiving 100 mg kg-1 gentamicin daily for 7 days. This was verified by high serum urea, uric acid, creatinine as well as increase in the levels of oxidative stress biomarkers as malondialdehyde, NO, total antioxidant capacity and decrease in reduced glutathione level. At any of the used regimen, 10 mg kg-1 gentamicin did not provide high compromise for renal functions nor significantly increased the oxidative stress and tissue damage. Based on microscopic lesions scores and biochemical analysis, there were no significant differences between single or two divided dosages of gentamicin at dose rate of 10 mg kg-1 day-1. Further studies are required for applications in other animals of human subjects.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effects on Renal Histology, Renal Metabolizing Enzymes and Oxidative Stress Biomarkers in Rats Administered Zerumbone Against Osteoarthritis
  •    Benfotiamine Ameliorate Gentamicin-induced Nephrotoxicity: Effect on Renal Oxidative Stress Markers and Plasma Platelets Activating Factor Acylhydrolase Activity
  •    Chemotherapeutic Agent-induced Nephrotoxicity in Rabbits: Protective Role of Grape Seed Extract
  •    The Protective Effects of Nigella sativa Oil and Allium sativum Extract on Amikacin-induced Nephrotoxicity
  •    Comparative Effects of Vitamin E and Kolaviron (a biflavonoid from Garcinia kola) on Carbon Tetrachloride-Induced Renal Oxidative Damage in Mice
  •    Evaluation of the Kidney Extract on Gentamicin Induced- Nephrotoxicity in Rat
  •    Nephrotoxicity Reduction by Fixed Dose Combination of Cephalosporins and Aminoglycosides in Mus musculus Mice
How to cite this article:

Mahmoud Kandeel, Iman Abdelaziz, Nagwan Elhabashy, Hanaa Hegazy and Yasmin Tolba, 2011. Nephrotoxicity and Oxidative Stress of Single Large Dose or Two Divided Doses of Gentamicin in Rats. Pakistan Journal of Biological Sciences, 14: 627-633.

DOI: 10.3923/pjbs.2011.627.633

URL: https://scialert.net/abstract/?doi=pjbs.2011.627.633

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom