Submit Manuscript

Kidney Research Journal

Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 24-32
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 250

Authors

Farzaneh Dehghani

M.R. Namavar

A. Noorafshan

S. Karbalay-Doust

T. Esmaeilpour

Keywords

Gentamicin (GM) is an aminoglycoside antibiotic that induces tubular necrosis, increases Blood Urea Nitrogen (BUN), Creatinine (Cr) and kidney atrophy. It has been proved that the kidney extract reduces the blood pressure. Perhaps, this extract may be having healing effects on kidney injury. The aim of this study was to evaluate the effects of kidney extract on GM-induced nephrotoxicity. For this purpose, thirty rats were divided into three groups. The gentamicin (GM) group received 100 mg kg-1 intraperitoneal injection whereas, gentamicin plus extract (GME) group received 100 mg kg-1 plus 30 mg kg-1 extract and control group received saline. After taking blood sample, the right kidneys were processed and stained with Hematoxylin-Eosin. Our findings showed that BUN and Cr increased in GM and GME groups in comparison with CON group. The length of Proximal Tubule (PT) decreased in the GM as compared to the control groups. The volumes of the kidney, cortex and medulla did not change in the GM and GME groups as compared to the CON group. It seems that GM decreases the length of PT; however, it has no effect on the volumes of the cortex and medulla. The kidney extract did not have healing effect on the structure of kidney in GM-induced nephrotoxicity.
PDF Fulltext XML References Citation

Related Articles

Study of Kidney Repair Mechanisms of Corn Silk (Zea mays L. Hair)-Binahong (Anredera cordifolia (Ten.) Steenis) Leaves Combination in Rat Model of Kidney Failure
The Acute Toxicity of Deisopropylngaione in Mice
Benfotiamine Ameliorate Gentamicin-induced Nephrotoxicity: Effect on Renal Oxidative Stress Markers and Plasma Platelets Activating Factor Acylhydrolase Activity
Nephrotoxicity and Oxidative Stress of Single Large Dose or Two Divided Doses of Gentamicin in Rats
Gentamicin and Phenylbutazone Nephrotoxicity in a Calf
Protective Effect of Zingiber officinale on Gentamicin-Induced Nephrotoxicity in Rats

Leave a Comment

Your email address will not be published. Required fields are marked *