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Pakistan Journal of Biological Sciences
  Year: 2000 | Volume: 3 | Issue: 12 | Page No.: 2188-2192
DOI: 10.3923/pjbs.2000.2188.2192
 
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Airway hyper-reactivity to histamin in clinically abnormal and experimentally sensitised horses
K.B. Mirbahar , W.N. McDonell and P. Eyre

Abstract:
Airway hyper-reactivity to histamine was studied in horses with respiratory disease (n=7) and in normal horses (n=4) selected on the basis of physical and laboratory examination. The animals were challenged with aerosolised histamine and the lung function was measured. The normal horses were sensitised to Ascaris suum and then challenged again with the same dose of histamine. The response of the same horse to the same dose of histamine before and after sensitisation were compared between themsevles and with diseased horses which suggested that the abnormal horses were hyper-reactive to histamine when compared to normal horses in which the reactivity to histamine was significantly were hyper-reactive to histamine when compared to the normal horses in which the reactivity to histamine was significantly greater after sensitisation. The response of normal horses after sensitisation to A. suum, resembled more with the abnormal group than with their own response before sensitisation. They studied suggest the presence of hyper-reactivity in horses suffering from respiratory disease and also suggest that hyper-reactivity can be induced in horses with experimental sensitisation.
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How to cite this article:

K.B. Mirbahar , W.N. McDonell and P. Eyre , 2000. Airway hyper-reactivity to histamin in clinically abnormal and experimentally sensitised horses. Pakistan Journal of Biological Sciences, 3: 2188-2192.

DOI: 10.3923/pjbs.2000.2188.2192

URL: https://scialert.net/abstract/?doi=pjbs.2000.2188.2192

 
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