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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 2 | Page No.: 101-112
DOI: 10.3923/jpt.2011.101.112
 
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Hypoglycemic Effect, Biochemical and Histological Changes of Spondias mombin Linn. and Parinari polyandra Benth. Seeds Ethanolic Extracts in Alloxan-induced Diabetic Rats

Emeka. E.J. Iweala and Funmilayo D. Oludare

Abstract:
The aim of this study was to evaluate the individual and synergistic hypoglycaemic and biochemical effects of the ethanolic extracts of seeds of Parinari polyandra and Spondias mombin in alloxan-induced diabetic rats. The ethanolic extracts of the seeds of Parinari polyandra and Spondias mombin were obtained by soxhlet extraction and administered to non-diabetic and alloxan-induced diabetic albino rats. Parameters including blood glucose, alanine aminotransferase (ALT), aspartate transaminase (AST), lipid peroxidation, triglycerides, cholesterol, glutathione and total protein were checked using standard test kits and methods after administration of the extracts. Histological changes in the liver of the animal were also examined. The results obtained revealed that alanine aminotransferase (ALT), aspartate transaminase (AST), lipid peroxidation, triglycerides, cholesterol and glutathione did not change significantly (p≤0.05) in the animals treated with the plant extracts. Glucose and total protein levels were significantly reduced (p≤0.05) in the animals treated with the plant extracts. The histological changes showed the presence of fatty cells in the liver of alloxan-induced diabetic control and non diabetic rats administered both Parinari polyandra and Spondias mombin extracts. The implications of the results obtained especially reduction of glucose by Parinari polyandra and Spondias mombin is their potential use in management of diabetes and apparent effects on the liver when administered together.
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How to cite this article:

Emeka. E.J. Iweala and Funmilayo D. Oludare, 2011. Hypoglycemic Effect, Biochemical and Histological Changes of Spondias mombin Linn. and Parinari polyandra Benth. Seeds Ethanolic Extracts in Alloxan-induced Diabetic Rats. Journal of Pharmacology and Toxicology, 6: 101-112.

DOI: 10.3923/jpt.2011.101.112

URL: https://scialert.net/abstract/?doi=jpt.2011.101.112

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