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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 5 | Page No.: 454-467
DOI: 10.3923/jpt.2011.454.467
 
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Hypoglycemic, Antidiabetic and Toxicological Evaluation of Momordica dioica Fruit Extracts in Alloxan Induced Diabetic Rats

Rambir Singh, Aarti Seherawat and Poonam Sharma

Abstract:
The aim of the study was to evaluate the antidiabetic effect of Momordica dioica fruit extracts in alloxan induced diabetic wistar rats. Aqueous extract of Momordica dioica (AEMD) showed maximum fall (52.8%) in 0 to 1 h Fasting Blood Glucose (FBG) in Glucose Tolerance Test (GTT) compared to hexane (39%), chloroform (37.2%) and ethanol (37.7%) extract in normal healthy rats. Since AEMD exhibited maximum hypoglycaemic activity as compared to other extracts, it was further studied for antidiabetic effect in diabetic rats. The oral Effective Dose (ED) of AMED was 200 mg kg-1 body weight which produced a fall of 57.5% (p<0.001) in diabetic rats. The 200 mg kg-1 body weight AMED once daily for 21 days reduced the elevated Blood Glucose (BG) by 64.8% (p<0.001), Post Prandial Glucose (PPG) by 76.9% (p<0.001) and glycosylated hemoglobin (HbA1c) by 37.6% (p<0.001). Urea, creatinine and urinary sugar, total protein, AST, ALT, alkaline phosphatase and bilirubin activities were also reduced after AEMD treatment in diabetic rats. Above 3 g kg-1 b.wt was Lethal dose of AEMD i.e., 15 times of ED indicating high margin of safety. Our study suggests possible use of aqueous extract of fruits of M. dioica for the management of diabetes mellitus.
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How to cite this article:

Rambir Singh, Aarti Seherawat and Poonam Sharma, 2011. Hypoglycemic, Antidiabetic and Toxicological Evaluation of Momordica dioica Fruit Extracts in Alloxan Induced Diabetic Rats. Journal of Pharmacology and Toxicology, 6: 454-467.

DOI: 10.3923/jpt.2011.454.467

URL: https://scialert.net/abstract/?doi=jpt.2011.454.467

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