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Journal of Medical Sciences

Year: 2008 | Volume: 8 | Issue: 4 | Page No.: 420-424
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Authors

M.T. Agyei-Frempong

F.N. Ghartey

S. Asante-Poku

B. Wiafe-Addai

Keywords

Research Article

A Cross Sectional View of Estrogen Receptors in 32 Human Breast Cancer Tissues in Ghana

M.T. Agyei-Frempong, F.N. Ghartey, S. Asante-Poku and B. Wiafe-Addai
The aim of this research was to determine the prevalence and proportion of estrogen-dependent, breast cancers in Ghana. Thirty two breast cancer tissues were obtained at random from patients seen at Komfo Anokye and Korle Bu Teaching Hospitals. Estrogen receptors were identified and quantitated using the cytosol-based dextran-coated charcoal assay. This was followed-up with a nationwide awareness and screening exercise from 1999 to 2002 to help improve awareness, encourage earlier detection and determine the prevalence of breast cancer in Ghana. Six out of 32 (18.75%, p>0.05) breast tumors were estrogen-dependent with receptor contents ranging from 12.75 to 101.31 (mean: 50.59±28.83) f mol mg-1 of cytosol protein. The mean tumor size was 12.58x 2.59 cm. Prevalence rate for breast cancer in Ghana ranged from 0.41-1.11% with a mean of 0.76±0.35% (at 95% confidence interval) among females aged 18 to 80 years. The mean age at diagnosis for breast cancer was 46.29 (±11.50) years/woman (confidence interval of ±22.54 years). Ghanaian women develop breast cancer some 10 to 15 years earlier than Caucasians and are less likely to respond to anti-estrogen therapy due to low proportion of estrogen receptor positive breast cancers.
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