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Status of Ki-67, Estrogen and Progesterone Receptors in Various Subtypes of Intracranial Meningiomas |
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Ashraf Fakhrjou,
Ali Meshkini and Sepideh Shadrvan |
Abstract:
Meningiomas are the most prevalent intracranial tumors in
human being. Although, majority of these cases are of benign nature, malignant
behavior might be seen in a number of patients. This study aimed to investigate
the status of estrogen receptor, progesterone receptor and Ki-67 labeling index
in different grades of surgical intracranial meningiomas. In this prospective
study, 50 patients with intracranial meningiomas were operated at the department
of neurosurgery, Tabriz Teaching Imam Reza Hospital; from February 2010 through
January 2012. Tumor grade was determined histopathologically according to the
World Health Organization (WHO) subtyping system. Status of estrogen and progesterone
receptor, as well as the Ki-67 labeling index was determined by immunohistochemical
approach and graded as 0 (absent), 1 (weak), 2 (moderate) and 3 (strong). The
group of patients comprised 15 males (30%) and 35 females (70%) with a mean
age of 71.76±10.20 (range: 49-87) years. WHO grades I, II and III tumors
were reported in 68, 22 and 10% of the cases, respectively. Estrogen receptor,
progesterone receptor and Ki-67 labeling index were detected in 20% (all grade
1), 98% (grade 1: 2%, grade 2: 22%, grade 3: 74%) and 38% (grade 1: 6%, grade
2: 22% and grade 3: 10%) of the cases, respectively. The rate of grade 1 estrogen
receptor was significantly higher in WHO grade I tumors (29%) than in WHO grades
II and III (zero for both, p = 0.02). Grade 2 progesterone receptor was significantly
higher in WHO grade II tumors (72.7%) vs. WHO grades I (8.8%) or III (0%). On
the other hand, the rate of grade 3 progesterone receptor was significantly
higher in WHO grades I (85.3%) and III (100%) tumors than in WHO grade II (27.3%)
(p = 0.01). The rate of grade 3 Ki-67 labeling index was significantly higher
in WHO grade III tumors (100%) than in WHO grades I and II (zero for both, p<0.001).
This study showed that firstly, estrogen receptor is seldom expressed in patients
with meningioma; however, its presence means a good prognosis. Secondly, Ki-67
labeling index is a marker of poor prognosis in these patients. Thirdly, although,
progesterone receptors are frequently expressed in meningioma, their prognostic
role varies greatly and needs to be determined in further studies.
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How to cite this article:
Ashraf Fakhrjou, Ali Meshkini and Sepideh Shadrvan, 2012. Status of Ki-67, Estrogen and Progesterone Receptors in Various Subtypes of Intracranial Meningiomas. Pakistan Journal of Biological Sciences, 15: 530-535.
DOI: 10.3923/pjbs.2012.530.535
URL: https://scialert.net/abstract/?doi=pjbs.2012.530.535
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