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Journal of Biological Sciences
  Year: 2006 | Volume: 6 | Issue: 2 | Page No.: 426-433
DOI: 10.3923/jbs.2006.426.433
 
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Evaluation of Anthelmintic Potential of Ethanolic Plant Extracts from Northern Cameroon Against Eggs and Infective Larvae of Haemonchus contortus

D. Monglo, L.M. Njongmeta, G. Musongong, M. Ngassoum and E.N. Nukenine

Abstract:
A commercial anthelmintic, Febendazole (Panacur) and ethanolic leaf extracts from five herbal plants (Annona senegalensis, Anogeissus leiocarpus, Lippia rugosa, Stereospermum kunthianum and Vernonia tonoreana), collected in the northern region of Cameroon in September 2001, were assessed for egg-inhibition ability as well as toxicity against the infective larval stage (third-instar) of Haemonchus contortus between January and March of 2002. The eggs and larvae were exposed to different concentrations (0, 0.1, 0.2, 0.4 and 0.8% (w/v)) of the test substances for 7 days and 1-48 h, respectively. Seven day EC50 and 6 and 48 h LC50 values were also determined. All the test substances induced a significant (p<0.01) dose-dependent inhibition of egg-hatch and larval mortality. Complete egg-hatch inhibition was recorded only for V. tonoreana, while the highest larval mortality of 98.33% was accomplished by A. senegalensis for the 0.8% level. Seven day EC50 and 48 h LC50 values were respectively 0.220 and 0.090% for Febendazole, 0.108 and 0.070% for A. senegalensis, 0.140 and 0.061% for A. leiocarpus, 0.299 and 0.129 for L. rugosa, 0.200 and 0.152% for S. kunthianum and 0.174 and 0.078% for V. tonoreana. Overall, the potency of the plant extracts was comparable to that of Febendazole, although the extracts from L. rugosa and S. kunthianum tended to be less active. The findings suggest these plants could yield natural alternative treatment products for H. contortus. However, further studies are required to determine their in vivo nematocidal properties.
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How to cite this article:

D. Monglo, L.M. Njongmeta, G. Musongong, M. Ngassoum and E.N. Nukenine, 2006. Evaluation of Anthelmintic Potential of Ethanolic Plant Extracts from Northern Cameroon Against Eggs and Infective Larvae of Haemonchus contortus. Journal of Biological Sciences, 6: 426-433.

DOI: 10.3923/jbs.2006.426.433

URL: https://scialert.net/abstract/?doi=jbs.2006.426.433

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