Subscribe Now Subscribe Today
Science Alert
Curve Top
Journal of Applied Sciences
  Year: 2011 | Volume: 11 | Issue: 15 | Page No.: 2700-2711
DOI: 10.3923/jas.2011.2700.2711
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Covalent Functionalization for Multi-walled Carbon Nanotube (f-MWCNT)-Folic Acid Bound Bioconjugate

Jacob M. Ngoy, Sunny E. Iyuke, Wilhelm E. Neuse and Clarence S. Yah

In the current concept, covalently functionalized multi-walled carbon nanotube (MWCNT) as a bioconjugate to folic acid (FA); an essential, bioavailable water soluble B-complex vitamin which is usually expressed on the surfaces of most tumoral cells was used. This was rendered possible through the design of a bioreversible binding water-soluble and biocompatible functionalized multi-walled carbon nanotubes (f-MWCNTs). The MWCNT was synthesized through the Chemical Vapor Deposition (CVD). The MWCNTs were covalently functionalized with sulphuric and nitric acids (3:1) at Room Temperature (RT), 50 and 100°C to generate the phenol and carboxyl groups. Furthermore, aspartic acid at 230°C was used to generate the carboxyl f-MWCNTs groups. The CNTs and f-MWCNTs were both characterized with the aid of a Transmission Electron Microscopy (TEM). The results showed a decreased in mol ratio (COOH/OH) of the f-CNTs from 80 to 20 nm as the temperature increases from RT to 100°C. The f-CNTs carboxyl were attached to 3-(N, N-dimethylamino) propylamine (DMP) and FA through 2-(1H-benzotrial-1-yl)-1, 1,3,3-tetramethylurium hexafluorophosphate (HBTU) to generate f-CNTs-FA conjugates. The results of the high resolution nuclear magnetic resonance (H1NMR) and infrared (IR) spectra showed CONH peak shifts bond bioreversible conjugation of FA at 94 and 101.3% and sizes 50 and 170 nm, respectively. The f-MWNT-FA moieties thereby have a greater versatility and can be used for the treatment and restoration of neoplasma cells.
PDF Fulltext XML References Citation Report Citation
  •    Green Synthesis of Manganese Oxide Nanoparticles from Cassia tora Leaves and its Toxicological Evaluation
  •    Structural Characterization of Selected Indian Coals by X-ray Diffraction and Spectroscopic Techniques
  •    Immobilization of Chitosan onto Carbon Nanotubes for Lead Removal from Water
  •    In vitro Toxicity of Multi Wall Carbon Nanoparticles on Hep G 32 Liver Cell Lines
  •    Comparison of Synthesis and Purification of Carbon Nanotubes by Thermal Chemical Vapor Deposition on the Nickel-Based Catalysts: NiSio2 and 304-Type Stainless Steel
  •    Application of Multiwalled Carbon Nanotube-Cyclodextrin Polymers in the Removal of Heavy Metals from Water
How to cite this article:

Jacob M. Ngoy, Sunny E. Iyuke, Wilhelm E. Neuse and Clarence S. Yah, 2011. Covalent Functionalization for Multi-walled Carbon Nanotube (f-MWCNT)-Folic Acid Bound Bioconjugate. Journal of Applied Sciences, 11: 2700-2711.

DOI: 10.3923/jas.2011.2700.2711






Curve Bottom