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International Journal of Zoological Research
  Year: 2008 | Volume: 4 | Issue: 3 | Page No.: 165-175
DOI: 10.3923/ijzr.2008.165.175
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Soybean Extract Antioxidant Protective Activity Against Copper-Induced Cytotoxicity

Mansour I. Almansour

The antioxidant activity of soybean crude extract against induced oxidative damage has been achieved through quails Coturnix coturnix treatment with various copper sulphate concentrations alone or with a protective dose of soybean crude extract. Several parameters of oxidative stress together with liver and kidney function tests in serum and liver tissue homogenate were studied. Hematologic indices and liver copper content were determined. Obtained data showed a significant increase in the serum activity of aspartate transaminase (AST), alanine transaminase (ALT) and malondialdehyde (MDA) content under a sever oxidative damage induced by highly copper sulphate treatments, also the total cholesterol, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and uric acid in addition to the antioxidant defense enzymes have been affected by copper toxicity in serum and liver homogenate. The results of the present investigation represented the protective activity of soybean phenolic compounds against the induced oxidative damage caused by copper toxicity. The protective antioxidant activity of soybean extract may be achieved through the inhibition of lipid peroxidation and membrane damage promoted by copper sulphate toxicity.
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How to cite this article:

Mansour I. Almansour , 2008. Soybean Extract Antioxidant Protective Activity Against Copper-Induced Cytotoxicity. International Journal of Zoological Research, 4: 165-175.

DOI: 10.3923/ijzr.2008.165.175






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