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International Journal of Zoological Research

Year: 2015 | Volume: 11 | Issue: 1 | Page No.: 9-18
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Authors

Firouzeh Gholampour

Seyed Moslem Fatemi Moghadam

Seyed Mohammad Owji

Keywords

This study investigated the effect of berberine on the renal dysfunction and histological damage induced by renal ischaemia/reperfusion at an early stage. There were four groups (n = 7). In Ber+I/R group, rats received berberine (Ber; 15 mg kg-1 day-1) orally for 7 days before induction of ischemia. The I/R group received distilled water orally for 7 days. In sham and Ber+sham groups, that renal arteries were not occluded, distilled water and berberin (15 mg kg-1 day-1), respectively were administered orally for 7 days before surgery. Renal ischemia was induced by occlusion of both renal arteries for 45 min followed by 24 h of reperfusion. Blood samples were collected for biochemical analysis and finally the left kidney was preserved for future histological examination. The renal ischaemic challenge resulted in major histological damages of the kidney which were associated with increased levels of creatinine and Blood Urea Nitrogen (BUN) at the end of reperfusion period. In Ber+I/R group, the histological damage to the kidney was improved along with increased in plasma creatinine and BUN being smaller than those of the non-treated rats. Berberine exhibited an ameliorative effect against renal ischemia/reperfusion-induced lesions.
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