• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 14 (6), 2018
  3. 866-872
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2018 | Volume: 14 | Issue: 6 | Page No.: 866-872
DOI: 10.3923/ijp.2018.866.872

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 132

Authors


Yuanyuan Liu

Country: China

Haili  Shen

Haili Shen

LiveDNA: 86.23212

Keywords


  • inflammatory markers
  • Osteoporosis
  • salvianolic acid B
  • ovariectomy
  • bone mineral density
Research Article

Salvianolic Acid B Administration Attenuate Bone Loss in Ovariectomy Induced Rat Model

Yuanyuan Liu and Haili Shen Haili  Shen's LiveDNA
Background and Objective: Osteoporosis is a chronic progressive skeletal disorder characterized by low Bone Mass Density (BMD) and bone quality. This study was aimed to access the anti-osteoporotic effects of salvianolic acid B (SAB-B) against ovariectomy-induced in rat model. Materials and Methods: Forty female (n = 40) rats were randomly chosen and divided into four groups as sham-operated control (underwent bilateral laparotomy; sham group, n=10), whereas rats underwent laparotomy followed by bilateral ovariectomy (ovariectomy model group; OVX, n= 10). Whereas, OVX underwent rats were orally supplemented with either 20 or 40 mg kg–1 of SAB-B (OVX+20 or 40 mg kg–1 SAB-B group; n= 10) for 12 weeks after 4 weeks of OVX. Statistical difference between the experimental groups were analyzed by student t-test using SPSS software at p<0.05. Results: Treatment with SAB-B (20 or 40 mg kg–1), substantially increased the body weight than OVX rats. A pronounced elevation in the levels of Bone Mineral Density/Content (BMD/BMC) and body weight were observed in SAB-B treated group as compared to OVX group. Bone markers like deoxypyridinoline, alkaline phosphatase and osteocalcin as well as inflammatory markers like IL-1β, IL-6, TNF-α concentrations were significantly abolished after 12 weeks of administration with SAB-A in OVX rats. Furthermore, the bone biomechanical stability was notably improved upon supplementation with SAB-B. Conclusion: Both SAB-B 20 and 40 mg kg–1 treatment exhibit potent anti-osteoporotic activity, nevertheless SAB-B 40 showed superior anti-osteoporotic activity than SAB-B 20. Therefore, SAB-B would be recommended for treating post-menopausal osteoporosis with other standard drugs.
PDF Fulltext XML References Citation

How to cite this article

Yuanyuan Liu and Haili Shen, 2018. Salvianolic Acid B Administration Attenuate Bone Loss in Ovariectomy Induced Rat Model. International Journal of Pharmacology, 14: 866-872.

DOI: 10.3923/ijp.2018.866.872

URL: https://scialert.net/abstract/?doi=ijp.2018.866.872

Related Articles

Chemoprotective Efficacy of Salvianolic Acid B via Triggering Apoptosis in MCF-7 Human Breast Cancer Cells
An Evidence-Based Review of Micro-CT Assessments of the Postmenopausal Osteoporosis Rat Model
Efficacy of L-Carnitine in the Treatment of Osteoporosis in Men

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved