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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 3 | Page No.: 157-172
DOI: 10.3923/ijp.2010.157.172
 
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Antioxidant Status of a Polyherbomineral Formulation (Gly-13-C) in STZ-Diabetic Rats

P. Ashok, A. Kyada, P. Subbarao, S. Suthar, D. Singh and K. Vadaliya

Abstract:
In the present investigation, antidiabetic and antioxidant activities of a polyherbomineral formulation, Gly-13-C was evaluated in streptozotocin-induced diabetic male Wistar rats and compared with that of glibenclamide (600 μg kg-1), a reference drug. After induction of diabetes by a single intraperitoneal injection of streptozotocin (65 mg kg-1), diabetic animals were treated with different doses of Gly-13-C (100, 200 mg kg-1 and 400 mg kg-1 b.wt.) for 21 days. Various biochemical parameters-fasting plasma glucose, albumin fructosamine levels, liver enzymatic antioxidants like superoxide dismutase, catalase, non-enzymatic antioxidants like vitamin C and E, lipid peroxidation in liver and glycogen biosynthesis in liver and skeletal muscle were measured. Study results showed that Gly-13-C 200 and 400 mg kg-1 b.wt. demonstrated better glycemic control and significantly protected liver tissue against oxidative damage than reference drug.
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How to cite this article:

P. Ashok, A. Kyada, P. Subbarao, S. Suthar, D. Singh and K. Vadaliya, 2010. Antioxidant Status of a Polyherbomineral Formulation (Gly-13-C) in STZ-Diabetic Rats. International Journal of Pharmacology, 6: 157-172.

DOI: 10.3923/ijp.2010.157.172

URL: https://scialert.net/abstract/?doi=ijp.2010.157.172

COMMENTS
04 August, 2010
Shaikh Azhar Hussain:
paper was good but you didnt gave the preperation of polyherbal formulation, please send me the soft copy of your thesis. thanking you
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