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Current Research in Poultry Science
  Year: 2011 | Volume: 1 | Issue: 2 | Page No.: 37-53
DOI: 10.3923/crpsaj.2011.37.53
 
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T Lymphocyte Selection is Indispensible for the Development of Goose Bursa of Fabricius

Qinghua Liu, Yan Wang, Yafei Cai, Huiling Liu, Jie Chen, Ping Li, Jienan Cheng and Honglin Liu

Abstract:
The process of T Lymphocyte involvement in the development of avian bursa of fabricius remains unclear. In order to clarify the feature of this process, the fetal goose bursas of fabricius from E17 (17-day-embryo) to 18 d (18-day after hatching) were adopted to study the morphological indices, 4 and CD8 co-localization in bursas of fabricius were determined by fluorescence microscopy. Cell apoptosis rate were analyzed the apoptosis with software Image Pro Plus 6.0. Like an appendix, the goose bursa of fabricius was located on the back of cloaca. The lymphatic follicle increased during the prenatal stage and became degenerated after hatching. For the first time, CD4 and CD8 co-expression (double positive) was found in the connective tissue and cortex and co-expression level increased from E17 to E26, then decreased from E28 to 7d. It was significantly different (p<0.01) among E17, E24, E26, E28, 18 and 3d. The apoptosis rate decreased from E17 to 3d, then dramatically increased after hatching and was extremely different (p<0.01) among E17, E24, E26, E28, 18 and 3d. The coordination between co-expression level and apoptosis rate in bursa of fabricius is significant. It is deduced that T lymphocyte selection in bursa of fabricius sharing the same feature as the T lymphocyte selection in thymus is indispensible for the development of goose bursa of fabricius.
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How to cite this article:

Qinghua Liu, Yan Wang, Yafei Cai, Huiling Liu, Jie Chen, Ping Li, Jienan Cheng and Honglin Liu, 2011. T Lymphocyte Selection is Indispensible for the Development of Goose Bursa of Fabricius. Current Research in Poultry Science, 1: 37-53.

DOI: 10.3923/crpsaj.2011.37.53

URL: https://scialert.net/abstract/?doi=crpsaj.2011.37.53

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