Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
American Journal of Drug Discovery and Development
  Year: 2013 | Volume: 3 | Issue: 4 | Page No.: 254-262
DOI: 10.3923/ajdd.2013.254.262
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Hypoglycemic, Hypolipidemic and Anti-free Radical Effects of Ethyl Acetate Extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae) Leaves in Streptozotocin-induced Diabetic Wistar Rats

Nwaehujor Chinaka O., Ode Julius O. and Asuzu Onyeka V.

Abstract:
The crude ethyl acetate extract of Bridelia micrantha leaves was tolerated orally in Wistar rats up to 2000 mg kg-1 without overt clinical manifestations. The extract demonstrated a high hypoglycemic potency in streptozotocin-induced diabetic rats. The effect of 300 and 600 mg kg-1 of the extract was most significant (p<0.01) and comparable to that of glibenclamide, the reference anti-diabetic agent at day 21 of treatment but in contrast to the untreated, control. In the in vivo antioxidant studies, the test doses (150, 300 and 600 mg kg-1) of the extract also exhibited equipotency with glibenclamide in preserving endogenous serum catalase and reduced glutathione. The extract remarkably suppressed lipid peroxidation and lowered total serum triglyceride as well as total serum cholesterol at 300 and 600 mg kg-1 relative to the control. Bridelia micrantha leaves could be a source of potent anti-diabetic, hypolipidemic and antioxidant compounds.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Hypoglycemic and Hypolipidemic Activity of Eugenia jambolana in Streptozotocin-diabetic Rats
  •    Anti-hyperglycemic Activities of Aqueous and Ethanolic Extracts Cynodon dactylon (Linn) Streptozotocin-induced Diabetic Rats
  •    Evaluation of Hypoglycemic and Hypolipidemic Activity of Methanolic Extract of Cocculus hirsutus (L.) Diels Leaves in Streptozotocin-Induced Diabetes Mellitus Rats
  •    The Effect of Equisetum arvense L. (Equisetaceae) in Histological Changes of Pancreatic β-Cells in Streptozotocin-Induced Diabetic in Rats
How to cite this article:

Nwaehujor Chinaka O., Ode Julius O. and Asuzu Onyeka V., 2013. Hypoglycemic, Hypolipidemic and Anti-free Radical Effects of Ethyl Acetate Extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae) Leaves in Streptozotocin-induced Diabetic Wistar Rats. American Journal of Drug Discovery and Development, 3: 254-262.

DOI: 10.3923/ajdd.2013.254.262

URL: https://scialert.net/abstract/?doi=ajdd.2013.254.262

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

Curve Bottom