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American Journal of Drug Discovery and Development
  Year: 2013 | Volume: 3 | Issue: 4 | Page No.: 254-262
DOI: 10.3923/ajdd.2013.254.262
Hypoglycemic, Hypolipidemic and Anti-free Radical Effects of Ethyl Acetate Extract of Bridelia micrantha (Hochst) Baill. (Euphorbiaceae) Leaves in Streptozotocin-induced Diabetic Wistar Rats
Nwaehujor Chinaka O., Ode Julius O. and Asuzu Onyeka V.

Abstract:
The crude ethyl acetate extract of Bridelia micrantha leaves was tolerated orally in Wistar rats up to 2000 mg kg-1 without overt clinical manifestations. The extract demonstrated a high hypoglycemic potency in streptozotocin-induced diabetic rats. The effect of 300 and 600 mg kg-1 of the extract was most significant (p<0.01) and comparable to that of glibenclamide, the reference anti-diabetic agent at day 21 of treatment but in contrast to the untreated, control. In the in vivo antioxidant studies, the test doses (150, 300 and 600 mg kg-1) of the extract also exhibited equipotency with glibenclamide in preserving endogenous serum catalase and reduced glutathione. The extract remarkably suppressed lipid peroxidation and lowered total serum triglyceride as well as total serum cholesterol at 300 and 600 mg kg-1 relative to the control. Bridelia micrantha leaves could be a source of potent anti-diabetic, hypolipidemic and antioxidant compounds.
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