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Asian Journal of Biological Sciences
  Year: 2018 | Volume: 11 | Issue: 4 | Page No.: 186-191
DOI: 10.3923/ajbs.2018.186.191
 
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Effects of Fermented Parkia biglobosa Seeds at Varied Dietary Inclusion on Liver Function of Albino Wistar Rat
Andrew Williams Alfa, David Sunday Abolude, Shuaibu Akpai Abdullahi, Clement Ameh Yaro and Meliga Salifu

Abstract:
Background and Objective: The popularity of contemporary emerging artificial condiments and their hazards on human health call for more empirical scientific evidences on the health indices of fermented Parkia biglobosa seeds. This study determined the effect of fermented Parkia biglobosa seeds on the serum levels of Total Bilirubin (TB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and associated histological changes of hepatocytes. Materials and Methods: The seeds were purchased at Bagana Market in Kogi state and fermented using traditionally method. Thirty five young adult Albino Wistar rats with average weight of 102 g were purchased from Institute of Veterinary Research, Vom, Plateau State. The rats were separated into 5 groups of 7 and allowed to acclimatize for 7 days before the commencement of the experimental feeding with 10, 20 and 30% of the FSB in the meals and 100% meals of FSB for 672 h in 4 groups while rats in the 5th group were fed with 100% pelletised grower mash for the same number of hours. They were fed Ad libitum with the meals and table water throughout the period. The blood and livers were harvested for enzyme assay using enzymatic assay kit obtained from Randox Laboratories Ltd. Co. Antrium, United Kingdom as well as light microscopy after staining the liver tissues with haematoxylin and eosin. Results: Analysis of variance showed significant increase (p<0.05) in the level of TB. However, hepatocytes, sinusoids and hepatic central vein showed no visible significant effect (p>0.05) on ALT and AST levels. The FSB inclusion at all percentages appeared not to show any negative effect on liver function of the Albino Wistar rats. Conclusion: Consistent intake of condiment prepared from fermented Parkia biglobosa seeds played significant role in the liver health by protecting the architecture of the liver and its functions.
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How to cite this article:

Andrew Williams Alfa, David Sunday Abolude, Shuaibu Akpai Abdullahi, Clement Ameh Yaro and Meliga Salifu, 2018. Effects of Fermented Parkia biglobosa Seeds at Varied Dietary Inclusion on Liver Function of Albino Wistar Rat. Asian Journal of Biological Sciences, 11: 186-191.

DOI: 10.3923/ajbs.2018.186.191

URL: https://scialert.net/abstract/?doi=ajbs.2018.186.191

 
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