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Trends in Medical Research

Year: 2007 | Volume: 2 | Issue: 2 | Page No.: 61-71
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Authors

Pitchai Balakumar

Manjeet Singh

Keywords

Research Article

Recent Advances in Pharmacotherapy for Heart Failure: Future Directions

Pitchai Balakumar and Manjeet Singh
Heart failure is a significant clinical challenge associated with high morbidity, mortality and economic burden in developing countries and the prevalence of chronic heart failure is continuously increasing. Heart failure is characterized by exercise intolerance, fatigability, dyspnea and volume retention occurring as a consequence of myocardial dysfunction. The drug therapies employed to treat heart failure like diuretics, vasodilators and inotropics have improved functional status of heart; but not decreasing long-term mortality. Recognition of neurohormones as important substances in the pathogenesis of heart failure has resulted in several treatment modalities including Angiotensin Converting Enzyme (ACE) inhibitors and β blockers that yield improvements of heart failure patients. But, heart failure is still a progressive disease with high morbidity and mortality. It suggests that vital pathogenic mechanisms remain active and unchanged by the present therapeutic strategies. Therefore, the need of new effective treatments for heart failure is mandatory. In this article, we review potential therapies insighted from recent studies of therapeutic interventions which may play as future drugs for heart failure.
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