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Trends in Medical Research
  Year: 2006 | Volume: 1 | Issue: 2 | Page No.: 113-121
DOI: 10.3923/tmr.2006.113.121
Indexing of Urinary Catecholamines and Metanephrines by Urinary Creatinine Levels in the Diagnosis of Phaeochromocytoma
Tigis Deboch, Donovan A. McGrowder and S. Shirley Budall

Abstract:
The study involved the investigation of the diagnostic utility of 24 h urinary excretion of catecholamines (epinephrine, norepinephrine and dopamine) and metanephrines (normetanephrine and metanephrine) and to compare with catecholamine-to-creatinine and metanephrine-to-creatinine ratio in the diagnosis of phaeochromocytoma. Retrospective study of 116 patients of which 4 had histologically confirmed phaeochromocytoma and 112 patients with essential hypertension. All measurements were performed using High Pressure Liquid Chromatography (HPLC) with Electrochemical Detection (ED) and the urine creatinine concentrations were measured by the Jaffe reaction. The four patients with phaeochromocytoma had mean 24 h urinary excretion rates of 1682.75±175.37 nmol/24 h for epinephrine (vs 54.38±4.61 nmol/24 h in hypertensive group), 16389.25±1295.22 nmol/24 h for fractionated normetanephrine (vs 2050.85±141.57 nmol/24 h in hypertensive group) and 21484.25±3882.60 nmol/24 h for fractionated metanephrine (vs 660.71±50.74 nmol/24 h in hypertensive group). There was excellent sensitivity and specificity for 24 h urinary excretion of fractionated metanephrine (100 and 92.9%) and normetanephrine (100 and 98.2%) for the diagnosis of phaeochromocytoma. The specificity of the metanephrine-to-creatinine ratio was 99.1% compared with 92.9% for fractionated metanephrine. Urinary excretion rate of normetanephrine and metanephrine-to-creatinine ratio are good discriminators of patients with essential hypertension and phaeochromocytoma with the latter test showing better specificity and positive predictive value compared with urinary excretion rate of fractionated metanephrine concentration.
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How to cite this article:

Tigis Deboch, Donovan A. McGrowder and S. Shirley Budall , 2006. Indexing of Urinary Catecholamines and Metanephrines by Urinary Creatinine Levels in the Diagnosis of Phaeochromocytoma. Trends in Medical Research, 1: 113-121.

DOI: 10.3923/tmr.2006.113.121

URL: https://scialert.net/abstract/?doi=tmr.2006.113.121

 
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