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Research Journal of Nanoscience and Nanotechnology

Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 34-41
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Authors

W. Simchua

N.A. Narkkong

Y. Baimark

Keywords

Research Article

Silk Fibroin Nanospheres for Controlled Gentamicin Sulfate Delivery

W. Simchua, N.A. Narkkong and Y. Baimark
The application of Silk Fibroin (SF) nanospheres for controlled-release drug delivery was investigated. Drug-loaded SF nanospheres were rapidly prepared by nanoprecipitation method from SF and drug aqueous solution by using acetone as a non-solvent. Gentamicin sulfate was used as a model water-soluble drug. The drug-loaded nanospheres with 160-180 nm in size were spherical in shape and had a smooth surface. The SF nanosphere matrices were changed from random coil to β-sheet conformation by acetone treatment and drug entrapment. FTIR spectroscopy and thermogravimetric analyses indicated intermolecular interactions between SF and drug molecules. The cumulative in vitro drug release profiles from SF nanospheres showed initial rapid burst release followed with sustained-release behaviors. The drug release rate increased with the decreasing drug ratio. All these findings suggest that the SF nanospheres are potentially useful in drug delivery systems, especially hydrophilic drugs.
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Comments

Veerababu Taduri Ramabrahmmam Reply

Dear Drs,

Over all the publication contains usage of interesting natural bio polymer.But this article lacks in-vivo studies data ,hopefully you are continuing the work in future.Also the nanoparticle
size determination by a Mavern autosizer in place of SEM is preferred for ease of application.
Overall this article opens gates for new biopolmer application to nanoparticles ,hence congratulations to you and your team for innovative work.
Thanks n Regards,

T.Veerababu.
General Manager -RnD
Sun Pharmaceutical Industries Limited ,
Vadodara .India.

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