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Research Journal of Medicinal Plants
  Year: 2014 | Volume: 8 | Issue: 4 | Page No.: 178-186
DOI: 10.3923/rjmp.2014.178.186
 
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Antihyperglycemic and Antihyperlipidemic Effects of Aqueous and Ethanolic Leaf Extracts of Vitex doniana in Streptozotocin-induced Diabetic Rats

Ibrahim Sani, Okpe Oche, Njoku Godwin Chiaka and Ndidi Uche Samuel

Abstract:
This study evaluated the effect of aqueous and ethanolic leaf extracts of Vitex doniana, against Streptozotocin (STZ) induced diabetic Wistar rats. Diabetes was induced with a single dose of Streptozotocin (60 mg kg-1 b.wt. i.p), followed by treatment with aqueous and ethanolic leaf extracts of V. doniana (100 and 200 mg kg-1 b.wt./day each), while metformin (25 mg kg-1 b.wt./day) was used as standard drug. The body weights and blood glucose levels were determined at the end of every week. Serum lipid profile was determined at the end of the experiment and the treatments were carried out for twenty-one days, after which the animals were sacrificed by humane decapitation. The results showed that significant difference (p<0.05) in Fasting Blood Glucose (FBG) between the diabetic treatment groups and Diabetic Control (DC) was observed at day fourteen, which remained consistent until the end of the experiment. All Diabetic treatment groups showed significant reduction (p<0.05) in triacylglycerol and cholesterol compared to the diabetic control group. Aqueous extract treatment groups significantly increased (p<0.05) the HDL-cholesterol compared to the diabetic control group while ethanolic leaf extract treatment groups showed no significant difference (p>0.05) in HDL-cholesterol compared to diabetic control group. All diabetic treatment groups reduced LDL-cholesterol, except 100 mg kg-1 b.wt. aqueous extract and 200 mg kg-1 b.wt. ethanolic extract. There was a decrease in body weights in all diabetic treatment groups. These results suggest that aqueous and ethanolic leaf extracts of V. doniana possess antihyperglycemic and antihyperlipidemic activity in STZ-induced diabetic rats.
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How to cite this article:

Ibrahim Sani, Okpe Oche, Njoku Godwin Chiaka and Ndidi Uche Samuel, 2014. Antihyperglycemic and Antihyperlipidemic Effects of Aqueous and Ethanolic Leaf Extracts of Vitex doniana in Streptozotocin-induced Diabetic Rats. Research Journal of Medicinal Plants, 8: 178-186.

DOI: 10.3923/rjmp.2014.178.186

URL: https://scialert.net/abstract/?doi=rjmp.2014.178.186

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