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Research Journal of Medicinal Plants
  Year: 2014 | Volume: 8 | Issue: 4 | Page No.: 156-166
DOI: 10.3923/rjmp.2014.156.166
 
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Effectiveness of Noni (Morinda citrifolia L.) Leaves Extract Gel as Standardized Traditional Medicine to Accelerate Oral Mucosa Wound Healing on Wistar Rats

E.R. Yuslianti, I.P. Rahmayani Sabirin and Afifah B. Sutjiatmo

Abstract:
Wound can be described as loss of tissue integrity which is a result of pathological change or physical trauma. Deficiency of immunity and bacterial invasion, as well as poor treatment, is significant problem of wound healing and it may be a cause of chronic wounds. Noni (Morinda citrifolia L.) leaf is a part of plant, empirically used to heal wounds or cuts. This study aims to analyze the role of noni leaves as oral antibacterial agent against Streptococcus mutans and to discover the role of noni leaves extract gel on oral mucosa wound healing based on fibroblast count and angiogenesis rate. This study was conducted by in vitro experimental laboratory design on Streptococcus mutans and in vivo on wistar rats. On the rats, wounds were made on palatal mucosa and they were divided into four groups; positive control group without wound, negative control group without treatment, 1st treatment group which was given 10% solution of povidone iodine and 2nd treatment group given 10% noni leaves ethanol extract gel. The development of wound was examined on days 3, 7 and 14. The result showed that noni leaf extracts in 6.25, 12.5, 25, 50 and 100%, respectively concentration were not able to inhibit the growth of Streptococcus mutans. However, 10% ethanolic extract of noni leaf had significant impact on palatal wound healing as observed on wound healing time, wound size, angiogenesis on 7th day and fibroblast count on 3rd and 7th day. Noni leaves ethanol extract could help oral mucosal wound healing based on angiogenesis examined and fibroblast cell count compared to other group. However, possibly noni leaves is not sensitive against Streptococcus mutans but according to a previous study, it had inhibitory effect for Staphylococcus aureus.
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How to cite this article:

E.R. Yuslianti, I.P. Rahmayani Sabirin and Afifah B. Sutjiatmo, 2014. Effectiveness of Noni (Morinda citrifolia L.) Leaves Extract Gel as Standardized Traditional Medicine to Accelerate Oral Mucosa Wound Healing on Wistar Rats. Research Journal of Medicinal Plants, 8: 156-166.

DOI: 10.3923/rjmp.2014.156.166

URL: https://scialert.net/abstract/?doi=rjmp.2014.156.166

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