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Hypoglycemic Activity of Lepidium sativum Linn Seed Total Alkaloid on Alloxan Induced Diabetic Rats |
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A. Shukla,
P. Bigoniya and B. Srivastava |
Abstract:
Lepidium sativum Linn. (Family Cruciferae) popularly known as Garden
cress has been used in traditional and folklore medicine for the treatment of
bronchial asthma, diabetes, local and rheumatic pain. The present study aimed
at investigation of antidiabetic efficacy of L. sativum Seed Total Alkaloid
(LSTA). The major components of this alkaloid fraction are lepidine and semilepidine,
a rare group of imidazole alkaloid. Antidiabetic profile of LSTA (50, 150 and
250 mg kg-1, i.p.) was assessed on alloxan induced diabetic rats
upon 21 days continuous treatment. Biochemical parameters viz., glucose, total
cholesterol, triglycerides, low density lipoprotein, high density lipoprotein,
urea and creatinine were determined along with b.wt. and relative organ weight.
LTSA at 250 mg kg-1 showed 1.94% b.wt. gain on 21th day relative
to 6.14 and 8.94% of control and diabetic group. LSTA at 250 mg kg-1
dose significantly (p<0.001) suppressed blood glucose, cholesterol, triglyceride
and urea level in diabetic rats. The results revealed that LSTA at dose 250
mg kg-1 showed potent hypoglycemic activity. The L. sativum
alkaloid have potential antidiabetic effect against alloxan-induced diabetes
may be through reducing oxidative damage and modulating antioxidant enzymes.
The possible mechanism by which LSTA brings about its anti-hyperglycaemic action
may be by potentiation of pancreatic secretion of insulin from the remaining
islet β cells.
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How to cite this article:
A. Shukla, P. Bigoniya and B. Srivastava, 2012. Hypoglycemic Activity of Lepidium sativum Linn Seed Total Alkaloid on Alloxan Induced Diabetic Rats. Research Journal of Medicinal Plants, 6: 587-596.
DOI: 10.3923/rjmp.2012.587.596
URL: https://scialert.net/abstract/?doi=rjmp.2012.587.596
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| COMMENTS |
21 September, 2012
Mushtaq Talib Abed:
thanx for releasing like a study but i have another like study indicating that lepidium sativum is effectie at dose 20mg\kg b.w. as anidiabetic. i plan to take like a subject in my master search.
Thanks
Pharmacist
Mushtaq T.Abed\Iraq |
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