• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Research Journal of Medicinal Plants
  2. Vol 6 (8), 2012
  3. 587-596
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Research Journal of Medicinal Plants

Year: 2012 | Volume: 6 | Issue: 8 | Page No.: 587-596

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 471

Search


Authors


A. Shukla

Country: India

P. Bigoniya

Country: India

B. Srivastava

Country: India

Keywords


  • hypoglycaemic
  • Lepidium sativum
  • seed
  • alloxan
  • imidazole alkaloid
Research Article

Hypoglycemic Activity of Lepidium sativum Linn Seed Total Alkaloid on Alloxan Induced Diabetic Rats

A. Shukla, P. Bigoniya and B. Srivastava
Lepidium sativum Linn. (Family Cruciferae) popularly known as Garden cress has been used in traditional and folklore medicine for the treatment of bronchial asthma, diabetes, local and rheumatic pain. The present study aimed at investigation of antidiabetic efficacy of L. sativum Seed Total Alkaloid (LSTA). The major components of this alkaloid fraction are lepidine and semilepidine, a rare group of imidazole alkaloid. Antidiabetic profile of LSTA (50, 150 and 250 mg kg-1, i.p.) was assessed on alloxan induced diabetic rats upon 21 days continuous treatment. Biochemical parameters viz., glucose, total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, urea and creatinine were determined along with b.wt. and relative organ weight. LTSA at 250 mg kg-1 showed 1.94% b.wt. gain on 21th day relative to 6.14 and 8.94% of control and diabetic group. LSTA at 250 mg kg-1 dose significantly (p<0.001) suppressed blood glucose, cholesterol, triglyceride and urea level in diabetic rats. The results revealed that LSTA at dose 250 mg kg-1 showed potent hypoglycemic activity. The L. sativum alkaloid have potential antidiabetic effect against alloxan-induced diabetes may be through reducing oxidative damage and modulating antioxidant enzymes. The possible mechanism by which LSTA brings about its anti-hyperglycaemic action may be by potentiation of pancreatic secretion of insulin from the remaining islet β cells.
PDF Fulltext XML References Citation

How to cite this article

A. Shukla, P. Bigoniya and B. Srivastava, 2012. Hypoglycemic Activity of Lepidium sativum Linn Seed Total Alkaloid on Alloxan Induced Diabetic Rats. Research Journal of Medicinal Plants, 6: 587-596.

URL: https://scialert.net/abstract/?doi=rjmp.2012.587.596

Comments


Mushtaq Talib Abed Reply
21 September, 2012

thanx for releasing like a study but i have another like study indicating that lepidium sativum is effectie at dose 20mg\kg b.w. as anidiabetic. i plan to take like a subject in my master search.
Thanks
Pharmacist
Mushtaq T.Abed\Iraq

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved