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Research Journal of Medicinal Plants
  Year: 2011 | Volume: 5 | Issue: 3 | Page No.: 288-294
DOI: 10.3923/rjmp.2011.288.294
 
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Antispasmodic Effects of Hydroalcoholic Extract from Gochnatia polymorpha sp. floccosa in the Guinea Pig Ileum

V. Schlemper, S.A. Freitas and S.R.M. Schlemper

Abstract:
The effects of hydroalcoholic extract from the leaves of Gochnatia polymorpha sp. floccosa on the contractile responses of the isolated guinea-pig ileum were investigated using a force displacement transducer amplifier connected to a physiograph. Isolated ileum preparations were set up for recording of isometric contractions in 5 mL jacketed organ baths containing oxygenated Krebs-Henseleit solution at 37°C under 1 g of load. G. polymorpha floccosa extract inhibited the contractile responses in a dose-dependent manner against different agonists. The profile of inhibition was noncompetitive to acetylcholine, histamine, serotonin and bradykinin-induced contractions. IC50s (and maximal inhibitions) values obtained were 247 μg mL-1 (83.1%), 818 μg mL-1 (72.62%), 450 μg mL-1 (75.82%) and 210.09 μg mL-1 (97.35%), respectively. These findings support the popular use in folk medicine of this plant as an antispasmodic on smooth muscles contractions.
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How to cite this article:

V. Schlemper, S.A. Freitas and S.R.M. Schlemper, 2011. Antispasmodic Effects of Hydroalcoholic Extract from Gochnatia polymorpha sp. floccosa in the Guinea Pig Ileum. Research Journal of Medicinal Plants, 5: 288-294.

DOI: 10.3923/rjmp.2011.288.294

URL: https://scialert.net/abstract/?doi=rjmp.2011.288.294

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