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Research Journal of Medicinal Plants

Year: 2011 | Volume: 5 | Issue: 3 | Page No.: 288-294
Research Article

Antispasmodic Effects of Hydroalcoholic Extract from Gochnatia polymorpha sp. floccosa in the Guinea Pig Ileum

V. Schlemper
Department of Biological and Health Sciences, School of Medicine, Universidade do Planalto Catarinense, Lages, SC, Brazil
S.A. Freitas
Department of Biological and Health Sciences, School of Medicine, Universidade do Planalto Catarinense, Lages, SC, Brazil
S.R.M. Schlemper
Department of Nutrition, Centro de Educação Superior Norte do Rio Grande do Sul, Universidade Federal de Santa Maria, Palmeira das Missões, RS, Brazil
The effects of hydroalcoholic extract from the leaves of Gochnatia polymorpha sp. floccosa on the contractile responses of the isolated guinea-pig ileum were investigated using a force displacement transducer amplifier connected to a physiograph. Isolated ileum preparations were set up for recording of isometric contractions in 5 mL jacketed organ baths containing oxygenated Krebs-Henseleit solution at 37°C under 1 g of load. G. polymorpha floccosa extract inhibited the contractile responses in a dose-dependent manner against different agonists. The profile of inhibition was noncompetitive to acetylcholine, histamine, serotonin and bradykinin-induced contractions. IC50s (and maximal inhibitions) values obtained were 247 μg mL-1 (83.1%), 818 μg mL-1 (72.62%), 450 μg mL-1 (75.82%) and 210.09 μg mL-1 (97.35%), respectively. These findings support the popular use in folk medicine of this plant as an antispasmodic on smooth muscles contractions.
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V. Schlemper, S.A. Freitas and S.R.M. Schlemper, 2011. Antispasmodic Effects of Hydroalcoholic Extract from Gochnatia polymorpha sp. floccosa in the Guinea Pig Ileum. Research Journal of Medicinal Plants, 5: 288-294.

URL: https://scialert.net/abstract/?doi=rjmp.2011.288.294

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