Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2009 | Volume: 3 | Issue: 2 | Page No.: 45-51
DOI: 10.3923/rjmp.2009.45.51
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Lipid Lowering Activity of Globimetula braunii

J. Okpuzor, G. Kareem and C. Ejikeme

Abstract:
Extract of Globimetula braunii in different solvent systems were evaluated for possible lipid and blood pressure lowering activities using in vivo and in vitro experimental methods. Dried Globimentula brauni leaves were pulverized into powder and successively extracted with methanol, hexane, chloroform, ethyl acetate, n-butanol and water using hot extraction methods. Normal male adult albino rats were administered a dosage of 200 mg kg-1 b.wt. of the extracts for a period of 14 days and the level of total cholesterol, triacylglycerol and lipid peroxidation were monitored. The crude extract of Globimetula braunii was analyzed for some antihypertensive substances using High Performance Liquid Chromatography (HPLC). The results obtained, showed that different fractions of the extract caused significant (p<0.05) decrease in serum total cholesterol, triacylglycerol and malonyldialdehyde (MDA) levels. HPLC elution profile showed that the crude extract contained substances similar to some known antihypertensive drugs like propanalol, lisinopril, moduretic and nifidipine and the lisinopril-like compound seems to be the most abundant by having the highest concentration. Thus, the data from this study suggests that Globimetula braunii extract contains some biologically active substances that may lower blood pressure and serum lipids.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effects of Plumeria alba Roots Hydro Alcoholic Extract on some Parameters of Type 2 Diabetes
  •    Serum Cholesterol as a Marker of Nutrition in End-stage Renal Failure Patients on Renal Replacement Therapy
How to cite this article:

J. Okpuzor, G. Kareem and C. Ejikeme, 2009. Lipid Lowering Activity of Globimetula braunii. Research Journal of Medicinal Plants, 3: 45-51.

DOI: 10.3923/rjmp.2009.45.51

URL: https://scialert.net/abstract/?doi=rjmp.2009.45.51

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

Curve Bottom