Submit Manuscript

Pakistan Journal of Biological Sciences

Year: 2023 | Volume: 26 | Issue: 2 | Page No.: 72-80
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 300

Authors

Wa Ode Harlis

Wa Ode Harlis

Jamili

Ruslin

Rahayu Malarangeng

Keywords

Research Article

Toxicity of Patiwala Leaf Extract (Lantana camara Linn.) as Antifertility Against Pregnancy in Rat (Mus musculus L.) Preimplantation Stage

Wa Ode Harlis Wa Ode Harlis's LiveDNA, Jamili, Ruslin and Rahayu Malarangeng
Background and Objective: Expert biological pest control is thought to be safer and to have fewer side effects. The use of plants carrying antifertility compounds is one method that can be developed to biologically reduce rat pest populations and thwart reproduction. This study aims to determine whether the toxicity of patiwala leaf extract (Lantana camara Linn.) can interfere with preimplantation stage rat (Mus musculus L.) pregnancy. Materials and Methods: This study was an experimental study arranged in a completely randomized design (CRD) consisting of 4 groups with 6 replications namely control (no treatment), patiwala leaf extract concentrations of 2 g/kg b.wt. (P1), 4 g/kg b.wt. (P2) and 6 g/kg b.wt. (P3). Mice were treated orally by gavage using a 1 mL disposable syringe on the 1st day of pregnancy (preimplantation) for three consecutive days. Mice were dissected at 16 days of gestation, observations were made of the percentage of implantation (%IM), the percentage of gestational loss (%KGE) and the percentage of postimplantation mortality (%KPI). Data were analyzed by Analysis of Variance (ANOVA) using KaleidaGraph 95% confidence level and Tukey’s HSD test. Results: The toxicity of patiwala leaf extract significantly interfered with the preimplantation stage of pregnancy in rats. The P3 treatment (6 g/kg b.wt.) gave a higher toxicity effect, namely, the percentage of implantation success was only 25.67%, the percentage increase in gestational loss was 74.26% and the percentage of post-implantation death was 66.67%. Conclusion: The patiwala leaf extract at a concentration of 6 g/kg b.wt., interfered with the pregnancy of preimplantation stage rats because it could reduce the number of live fetuses.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *