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Pakistan Journal of Biological Sciences

Year: 2013 | Volume: 16 | Issue: 23 | Page No.: 1796-1800
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Authors

Hasan Imam

Nasir Uddin Mahbub

Md. Forhad Khan

Humayera Kabir Hana

Md. Moklesur Rahman Sarker

Keywords

Previously it was reported elsewhere that Lawsonia inermis have anti-inflammatory and analgesic effect in experimental animals. The in vitro porcine alpha amylase inhibitory effect was investigated of this plant methanolic extracts and consequently hypoglycemic effect by quantitatively determining the maltose from the maltose standard curve while the anti-inflammatory effect by acetic acid induced writhing test in mice. Acarbose (10 μg mL-1) and Diclofenac sodium (20 mg kg-1) were used as reference hypoglycemic and anti-inflammatory drugs, respectively, for this study. The methanolic leaves extract of the plant significantly inhibited (60.97% compared to untreated) enzymatic activity of the amylase at 10 μg mL-1 dose (p<0.05) also reduced the chemically induced nociceptive pain stimuli significantly at all doses (p<0.01). Carbohydrates, glycosides, flavonoids, saponins and tannins were found to have in phytochemical screening of the extract which are thought to bring these effects. For the conclusive purpose, it is suggesting from the result that the pharmacological properties of this Lawsonia inermis can elicit hypoglycemic effect by inhibiting α-amylase enzyme and can reduce neurogenic pain stimulus. It gives the notion that how this group of patient would be therapeutically benefitted by decreasing both these effects by the same agent which is easy available.
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