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Purification, Characterization and Toxic Profile of Two Toxins Isolated from Puffer Fish Tetraodon patoca, Available in Bangladesh |
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Sohel Hasan,
M.M. Rahman,
T. Hossain,
A. Mosaddik,
S. Khatun and N. Absar |
Abstract:
Among the marine toxins related to human intoxication,
tetrodotoxin has been known as one of the most prejudicial. Two tetrodotoxins,
namely PFT-1 and PFT-2 were isolated and purified from liver of puffer
fish by thin layer chromatography. The structure of both the toxins was
elucidated by means of IR, 1H-NMR and 13C-NMR and
mass spectroscopy. Sub acute toxicity study showed that both the toxins
had pronounced effects on total RBC, WBC, platelet and ESR. Further serum
levels of SGPT, SGOT, SALP, bilirubin, creatinine and urea are also affected
by the toxins. The histopathological examinations showed that all the
tissues such as liver, lung, heart and kidney of rat were severely changed
after treatment with the toxins. The toxicity of the purified compounds,
PFT-1 and PFT-2 were also performed by brine shrimp lethality bioassay.
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How to cite this article:
Sohel Hasan, M.M. Rahman, T. Hossain, A. Mosaddik, S. Khatun and N. Absar, 2007. Purification, Characterization and Toxic Profile of Two Toxins Isolated from Puffer Fish Tetraodon patoca, Available in Bangladesh. Pakistan Journal of Biological Sciences, 10: 773-777.
DOI: 10.3923/pjbs.2007.773.777
URL: https://scialert.net/abstract/?doi=pjbs.2007.773.777
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