Submit Manuscript

Pakistan Journal of Biological Sciences

Year: 2007 | Volume: 10 | Issue: 16 | Page No.: 2728-2731
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 1277

Search

Authors

Mohamad K. Nusier

Hameed N. Bataineh

Haytham M. Daradka

Keywords

Research Article

Adverse Effects of Propranolol on Reproductive Function in Adult Male Mice

Mohamad K. Nusier, Hameed N. Bataineh and Haytham M. Daradka
Ingestion of propranolol at 10 and 15 mg kg-1 body weight for 35 days by adult male mice was investigated for its effects on fertility. Body weight and absolute and relative testes weights were reduced and the average weights of epididymis, ventral prostate and seminal vesicle decreased significantly. A significant decline of spermatogenesis in testes due to a decrease in the number of primary, secondary spermatocytes and spermatids in the treatment group 2 (15 mg kg-1) is attributed to a significant decrease in testosterone, LH and FSH. Sperm motility and density were also significantly decreased in the cauda epididymis and in the testes of group 2 treated male mice. In addition, the treatment markedly increased the number of fetal resorptions in female mice impregnated by the group 2 males, thereby reducing their fertility.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *