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Pakistan Journal of Biological Sciences
  Year: 2006 | Volume: 9 | Issue: 10 | Page No.: 1935-1939
DOI: 10.3923/pjbs.2006.1935.1939
 
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Studies on the Antimicrobial Effect of Allicin on the Intra Macrophages Brucella
Reza Shapoury, Morteza Sattari and Zuhair M. Hassan

Abstract:
Brucella sp. are facultative intracellular bacteria that capable of surviving inside professional and nonprofessional phagocytes. The most important virulence factors of Brucella are related to its capability of intra macrophage survival. Allicin the major component of garlic (Allium sativum) has antimicrobial activity and was examined for the ability to induce immune responses in murine peritoneal macrophages. In this study, garlic choloroformic extract prepared and quantity of allicin calculated with HPLC, then effect of extract on intramacrophage survival of B. melitensis Rev.1 and B. abortus S19 on cell culture of mouse peritoneal macrophages studied. Results indicated that extract was effective and eradicated intramacrophage brucellae in 1:40 (equal with 439 μg mL-1 allicin), :80 (218 μg mL-1 allicin) and 1:160 (128 μg mL-1 allicin) extract dilutions after 24 h. To give attention to antimicrobial effect of garlic on intramacrophages Brucella, it seems to be useful in treatment of brucellosis.
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How to cite this article:

Reza Shapoury, Morteza Sattari and Zuhair M. Hassan , 2006. Studies on the Antimicrobial Effect of Allicin on the Intra Macrophages Brucella. Pakistan Journal of Biological Sciences, 9: 1935-1939.

DOI: 10.3923/pjbs.2006.1935.1939

URL: https://scialert.net/abstract/?doi=pjbs.2006.1935.1939

 
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