Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2006 | Volume: 9 | Issue: 10 | Page No.: 1852-1860
DOI: 10.3923/pjbs.2006.1852.1860
Apoptosis-Sialic Acid Relationships at Different Developmental Stages of Murine Thymus
Erdal Balcan and Mesut Sahin

Abstract:
During the maturation stages of thymocytes, apoptosis plays a crucial role for the production of immunocompetent T cells. On the other hand, changes of glycosylation may influence both T cell signaling and T cell development. Carbohydrate molecules are not only energy sources of the cells, but they can also responsible for the recognition phenomena such as protein targeting and cell to cell interactions. Therefore, glycosylation of cell surface proteins or lipids controls critical T cell processes, such as T cell death. Sialic acids, terminal sugar of the glycan motifs, are primarily responsible for the cellular interactions. In the present study, we purposed to determine of the cell surface carbohydrate alterations and the possible relationships of apoptosis with these alterations in the thymocytes from different periods of embryonic and newborn thymic tissues. Our terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) staining indicated that the thymocyte apoptosis is increased after the day 16of embryonic development and it proceeds in neonatal period. In addition, the surface density of sialic acids were decreased in newborn thymi when compared to embryonic tissues. These results indicated that, there is a significant relationship between cell surface sialic intensities and apoptosis. Thus, in the embryonic development, pathways which responsible for the thymocyte apoptosis may different from those of the newborn period due to masking effects of sialic acids. However, after the birth, sialic acid intensities were highly diminished in the thymocytes and, therefore they may undergo to apoptosis by another pathway(s), such as galactin-1 induced pathway.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    How to Cope with Dengue in Developing Countries Like Pakistan?
How to cite this article:

Erdal Balcan and Mesut Sahin , 2006. Apoptosis-Sialic Acid Relationships at Different Developmental Stages of Murine Thymus. Pakistan Journal of Biological Sciences, 9: 1852-1860.

DOI: 10.3923/pjbs.2006.1852.1860

URL: https://scialert.net/abstract/?doi=pjbs.2006.1852.1860

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom