
	Pakistan Journal of Biological Sciences
	Year: 2005 \| Volume: 8 \| Issue: 9 \| Page No.: 1272-1274 DOI: 10.3923/pjbs.2005.1272.1274

Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis

Abbas Hajifathali , Bahram Kazemi , Aliakbar Pourfathollah , Ghasem Rastegar Lari and Rouzbeh Chegeni

Abstract: Human coagulation factor V serves as a cofactor for factor X in thrombin formation. Generation of thrombin leads to fibrin and clot formation. In this study 65 patients were selected with venous thrombosis. Patients with a positive Protein C resistance were chosen and screened genetically by Conformation Sensitive Gel Electrophoresis (CSGE) for the presence of factor V mutations, the suspected mutations were sequenced. Three new mutations were found as follows, Met 385 thr, Met 1736 Val and Lys 386 Lys. Present study shows factor V mutations leading to thrombosis that have been never reported in Iran

PDF References Citation Report Citation

RELATED ARTICLES:

•	Coagulation Factors Evaluation in NIDDM Patients

How to cite this article:

Abbas Hajifathali , Bahram Kazemi , Aliakbar Pourfathollah , Ghasem Rastegar Lari and Rouzbeh Chegeni , 2005. Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis. Pakistan Journal of Biological Sciences, 8: 1272-1274.

DOI: 10.3923/pjbs.2005.1272.1274

URL: https://scialert.net/abstract/?doi=pjbs.2005.1272.1274

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI

Science Alert