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Pakistan Journal of Biological Sciences
  Year: 2005 | Volume: 8 | Issue: 9 | Page No.: 1272-1274
DOI: 10.3923/pjbs.2005.1272.1274
 
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Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis

Abbas Hajifathali , Bahram Kazemi , Aliakbar Pourfathollah , Ghasem Rastegar Lari and Rouzbeh Chegeni

Abstract:
Human coagulation factor V serves as a cofactor for factor X in thrombin formation. Generation of thrombin leads to fibrin and clot formation. In this study 65 patients were selected with venous thrombosis. Patients with a positive Protein C resistance were chosen and screened genetically by Conformation Sensitive Gel Electrophoresis (CSGE) for the presence of factor V mutations, the suspected mutations were sequenced. Three new mutations were found as follows, Met 385 thr, Met 1736 Val and Lys 386 Lys. Present study shows factor V mutations leading to thrombosis that have been never reported in Iran
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How to cite this article:

Abbas Hajifathali , Bahram Kazemi , Aliakbar Pourfathollah , Ghasem Rastegar Lari and Rouzbeh Chegeni , 2005. Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis. Pakistan Journal of Biological Sciences, 8: 1272-1274.

DOI: 10.3923/pjbs.2005.1272.1274

URL: https://scialert.net/abstract/?doi=pjbs.2005.1272.1274

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