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Pakistan Journal of Biological Sciences
  Year: 2003 | Volume: 6 | Issue: 4 | Page No.: 359-362
DOI: 10.3923/pjbs.2003.359.362
 
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Pesticide-induced Changes in Serum Levels of Acid Phosphatase, Alkaline Phosphates and Glutamate Oxaloacetate Transaminase in Rats

Muhammad Nasim Khan and Tahira Sarwar

Abstract:
Three insecticides (Monitor, Talstar and Benzenehexachloride {BHC}), orally administered at the doses of 0.06, 0.5 and 0.2 mg kg-1 body weight respectively for 21 days affected the body weight and biochemical environment of blood and liver in the rats. Talstar treatment resulted in an increase in the body weight while Monitor and BHC treatment reduced the body weight. After 21 days of the Monitor treatment, activities of acid phosphatases increased (55%) and alkaline phosphates decreased (2%) in the serum while slight inhibition was observed in the serum glutamate oxaloacetate transaminase activity. Benzenehexachloride treatment resulted in increased serum levels of acid phosphatase, alkaline phosphatase and glutamate oxaloacetate transaminase (42, 2 and 18% respectively). Talstar treatment decreased the activities of acid phosphatase and alkaline phosphatase (76 and 5%, respectively) while glutamate oxaloacetate transaminase activity was increased (25%). These data suggest that chronic exposure to Monitor, Talstar and BHC causes hepatocyte necrosis and increases the liver enzyme synthesis.
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How to cite this article:

Muhammad Nasim Khan and Tahira Sarwar, 2003. Pesticide-induced Changes in Serum Levels of Acid Phosphatase, Alkaline Phosphates and Glutamate Oxaloacetate Transaminase in Rats. Pakistan Journal of Biological Sciences, 6: 359-362.

DOI: 10.3923/pjbs.2003.359.362

URL: https://scialert.net/abstract/?doi=pjbs.2003.359.362

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