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Protective Effect of SO-SeNPs against DOX-induced Liver Toxicity and its Mechanism in Rats |
Wafaa E. Shinkar,
Hadeer Mabo Ashour,
Mohamed I. Shalfota,
Hayam N. Ibrahim  ,
Esraa K. Fawzy,
Esraa A. Abdelmotaleb,
Hanan M. Atea,
Dina K. Mohamed,
Youssef M. Hussien,
Ehab S. Kotp,
Ahmed A. Emara and Mohammed A. Hussein |
Abstract:
Background and Objective: The administration of DOX induces hepatotoxicity by ROS and cytokines production that result in imbalanced redox potential that leads to oxidative stress, reduced antioxidant enzyme content. This study aimed to evaluate the protective activity of SO-SeNPs in rats against liver toxicity induced by DOX. Materials and Methods: In the current study, particle size and zeta potential SO-SeNPs was prepared and characterized. In addition, IC50 and LD50 SO-SeNPs were calculated. The liver-protective action of SO-SeNPs against DOX-induced liver toxicity of rats was assessed by 16 adult albino rats. Results: The SO-SeNPs were approximately 148.14±14.68 Nm tall with −29.4±0.84 negative zeta potential. IC50 for the Hep-G2 cell line and LD50 is equal to 161.17 μg mL–1 and 1650 mg kg–1 b.wt. A significant increase in plasma ALT, asT, asT and LDH as well as liver MDA, TNF-α, IL-6 and P53 has been observed through the 30 days of daily oral administration of SO-SeNPs at 33 and 82.5 mg kg–1 b.wt. to rats treated with DOX (20 mg kg–1 b.wt.). Oral SO-SeNP administration has increased SOD, GPx and GSH, on the other hand and in rats treated with DOX. The SO-SeNPs have also nearly normalized these DOX effects in the liver tissue. Conclusion: Current study's biochemical, histological and MRI results showed that SO-SeNPs have liver protective activity against DOX-induced liver toxicity in rats.
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How to cite this article:
Wafaa E. Shinkar, Hadeer Mabo Ashour, Mohamed I. Shalfota, Hayam N. Ibrahim, Esraa K. Fawzy, Esraa A. Abdelmotaleb, Hanan M. Atea, Dina K. Mohamed, Youssef M. Hussien, Ehab S. Kotp, Ahmed A. Emara and Mohammed A. Hussein, 2021. Protective Effect of SO-SeNPs against DOX-induced Liver Toxicity and its Mechanism in Rats. Pharmacologia, 12: 1-10.
DOI: 10.17311/pharmacologia.2021.1.10
URL: https://scialert.net/abstract/?doi=pharmacologia.2021.1.10
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