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Journal of Pharmacology and Toxicology

Year: 2023 | Volume: 18 | Issue: 3 | Page No.: 150-157
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Authors

Sawadogo Assétou

Sawadogo Assétou

Sore Harouna

Sore Harouna

Meda Nâg-Tiéro Roland

Belem Hadidjatou

Belem Hadidjatou

Koama Kouliga Benjamin

Koama Kouliga Benjamin

Yougoubo Abdoulaye

Ganame Arouna

Roamba Noëlle Edwige

Kagambega Windmi

Ouedraogo Georges-Anicet

Keywords

Background and Objective: Malaria remains one of the most deadly diseases in developing countries. Most populations in these countries use fold medicine without any scientific evidence. In the present study, the in vitro antiplasmodial activity has been assessed from five medicinal plants commonly used traditionally in Burkina Faso to treat malaria. Materials and Methods: Thus, Spermacoce verticillata, Gardenia erubescens, Mitracarpus villosus, Fadogia agrestis and Mitragyna inermis belonging to the Rubiaceae family were extracted with water, ethanol, methanol, dichloromethane and hexane. Total phenolics and total flavonoids were determined by colorimetric methods. The Plasmodium lactate dehydrogenase assay was used to determine the drug susceptibility. The cytotoxicity was determined with the red blood cells by the calculation of the percentage of hemolysis. Results: The results indicated that most of the extracts had total phenolics and total flavonoids. All aqueous and hexanic extracts of the five plants failed to inhibit parasite growth. However, ethanolic macerate of Fadogia agrestis and ethanolic extract to the soxhlet of Spermacoce verticillata significantly inhibited the growth of 3D7 parasites with IC50s of 9.56±0.63 and 6.86±0.39 μg mL–1, respectively. The percentage of hemolysis in all extracts was less than 5% indicating the hemolysis effects of the extracts. Conclusion: Current study showed that Spermacoce verticillata and Fadogia agrestis exhibited good antiplasmodial activity in vitro. Bio-guided phytochemical studies could lead to interesting natural molecules with antiplasmodial activity.
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Sawadogo Assétou, Sore Harouna, Meda Nâg-Tiéro Roland, Belem Hadidjatou, Koama Kouliga Benjamin, Yougoubo Abdoulaye, Ganame Arouna, Roamba Noëlle Edwige, Kagambega Windmi and Ouedraogo Georges-Anicet, 2023. In vitro Antiplasmodial Properties of Five Antimalarial Plants Used in Burkina Faso. Journal of Pharmacology and Toxicology, 18: 150-157.

DOI: 10.3923/jpt.2023.150.157

URL: https://scialert.net/abstract/?doi=jpt.2023.150.157

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