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Journal of Pharmacology and Toxicology
  Year: 2020 | Volume: 15 | Issue: 1 | Page No.: 36-43
DOI: 10.3923/jpt.2020.36.43
 
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Curative Effect of Terminalia superba Engl. and Diels (Combretaceae) Trunk Bark on Paracetamol-induced Hepatotoxicity in Rats
Goze Nomane Bernard, Oussou N'guessan Jean-Baptiste, Kouakou Kouakou Léandre, Koko Kouamé Paul and Yapo Angoué Paul

Abstract:
Background and Objective: Terminalia superba is a plant used in traditional medicine to treat various ailments. This study aims at assessing the curative potential of a total aqueous extract of the trunk bark of T. superba (TAETs) on paracetamol-induced hepatotoxicity in rats. Materials and Methods: Except the control group which received distilled water, 3 groups of 6 rats were daily gavaged with 2 g kg1 b.wt. of paracetamol within 3 days. Later on, distilled water, 100 mg kg1 b.wt. of silymarin and 500 mg kg1 b.wt. of T. superba extract were daily administered for10 days to the respective groups of rats by oral route. At the end of the experiment, rats were administered with phenobarbital (80 mg kg1 b.wt., ip) in order to determine their sleeping time. Some blood samples were taken at the beginning of the experiment, on the 3rd day and the last day for liver biomarkers determination. The rats were sacrificed, livers were removed, macroscopically observed and weighed. Results: The TAETs decrease biomarkers (AST, ALT, alkaline phosphatase, total and conjugated bilirubin) and sleeping time increased by paracetamol. These results are similar to that of silymarin. Conclusion: The TAETs have hepatocurative effects by normalizing paracetamol-induced changes in serum liver biomarkers and reducing phenobarbital-induced sleep time in the presence of paracetamol.
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How to cite this article:

Goze Nomane Bernard, Oussou N'guessan Jean-Baptiste, Kouakou Kouakou Léandre, Koko Kouamé Paul and Yapo Angoué Paul, 2020. Curative Effect of Terminalia superba Engl. and Diels (Combretaceae) Trunk Bark on Paracetamol-induced Hepatotoxicity in Rats. Journal of Pharmacology and Toxicology, 15: 36-43.

DOI: 10.3923/jpt.2020.36.43

URL: https://scialert.net/abstract/?doi=jpt.2020.36.43

 
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