Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2009 | Volume: 4 | Issue: 2 | Page No.: 58-69
DOI: 10.3923/jpt.2009.58.69
Dibutylnitrosamine Induces Histopathological Changes in Rat: Possible Protective Effects of Cinnamon Flavonoid Extract
Y.A. Elhassaneen, S.A. Saleh, S.F. El-Abd, M.M. El-Sayed and N.N. El-Nashar

Abstract:
The aim of this study was to investigate the protective role of Cinnamon Flavonoid Extract (CFE) against histopathological changes in albino rats of Wistar strain treated with Dibutylnitrosamine (DBNA) for 12 weeks. The results indicated that rats treated with DBNA recorded decreasing in the total body and liver weights and increasing in spleen and kidney weights with significant values when compared with the control group all over the experiment period 4, 8 and 12 weeks. Addition of CFE by 150 and 300 mg kg-1 b.wt./day in the presence of nitrosamine induced significant improvements in all organs weights. Also, DBNA treated group had histopathological changes on liver through degeneration hyperemia, inflammatory reaction, kidney through hemorrhages renal casts hyperemia, inflammatory reaction and also urinary bladder through papillary hyperplasia with papillary projection formation in the cell layer of the lining epithelium. The co-treatment of CFE with DBNA leads to prevent some of the previous histopathological changes mainly on liver and urinary bladder and secondary on the kidney. It could be concluded that CFE was effective in protecting against DBNA-induced histopathological changes. These results supported present hypothesis that CFE contains several compounds that are able to prevent or inhibit DBNA toxicity.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
How to cite this article:

Y.A. Elhassaneen, S.A. Saleh, S.F. El-Abd, M.M. El-Sayed and N.N. El-Nashar, 2009. Dibutylnitrosamine Induces Histopathological Changes in Rat: Possible Protective Effects of Cinnamon Flavonoid Extract. Journal of Pharmacology and Toxicology, 4: 58-69.

DOI: 10.3923/jpt.2009.58.69

URL: https://scialert.net/abstract/?doi=jpt.2009.58.69

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

Curve Bottom