In vitro Study on the Interaction of Caffeine with Gliclazide and Metformin in the Aqueous Media

Research Article

In vitro Study on the Interaction of Caffeine with Gliclazide and Metformin in the Aqueous Media

Mohammad Mohiuddin, A.T.M. Zafrul Azam, Md. Shah Amran and Md. Amjad Hossain

An in vitro study of interaction of caffeine with gliclazide and metformin HCl has been studied at room temperature and at different pH. It has been found that caffeine forms stable 1:1 molecular complexes with gliclazide and metformin HCl. The studies have been carried out by various UV spectrophotometric and conductometric methods. Observation of the UV spectra of the two molecules in presence of caffeine has indication that it reacts with the anti-diabetic agents. The conductometric method was used to further ascertain about the nature of interaction and stoichiometries. The Ardon’s Spectrophotometric method confirmed the formation of 1:1 molecular complexes and led to calculate the stability constants. It has been observed that the stability constants for caffeine-gliclazide system were higher than that of caffeine-metformin HCl system in all pH conditions.

PDF Fulltext XML References Citation

How to cite this article

Mohammad Mohiuddin, A.T.M. Zafrul Azam, Md. Shah Amran and Md. Amjad Hossain, 2009. In vitro Study on the Interaction of Caffeine with Gliclazide and Metformin in the Aqueous Media. Journal of Pharmacology and Toxicology, 4: 194-204.

DOI: 10.3923/jpt.2009.194.204

URL: https://scialert.net/abstract/?doi=jpt.2009.194.204

Journal of Pharmacology and Toxicology

Article Trend

Total views 96

Authors

Mohammad Mohiuddin

A.T.M. Zafrul Azam

Md. Shah Amran

Md. Amjad Hossain

Keywords

Research Article

In vitro Study on the Interaction of Caffeine with Gliclazide and Metformin in the Aqueous Media

How to cite this article

Leave a Comment