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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 8 | Page No.: 743-747
DOI: 10.3923/jpt.2007.743.747
 
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Studies on the Toxicity of Ageratum conyzoides

A.C. Igboasoiyi, O.A. Eseyin , N.K. Ezenwa and H.O. Oladimeji

Abstract:
The mean lethal dose of ethanolic extract of Ageratum conyzoides was evaluated. Serum levels of some enzymes and biomolecules were also evaluated after a daily oral administration of 500 and 1000 mg kg-1 of the extract for 28 days. The enzymes and biomolecules evaluated were: Alanine and Aspartate aminotransferases, alkaline phosphatase, amylose, glucose, total proteins, creatinine, cholesterol, high density, low density-and very low density-lipoproteins. The result showed that the LD50 of Ageratum conyzoides was 10,100 mg kg-1. the extract did not significantly affect serum levels of alanine and aspartate transaminases, alkaline phosphatase, amylase, creatinine, glucose and total proteins at any of the two dose levels. the extract however reduced significantly the serum level of cholesterol and high density lipoproteins. One thousand milligram per kilogram of the extract also enhanced growth of the animals as observed in the weight increase of the rats. The results of this work showed that the extract of A. conyzoides at the dose of 500 and 1000 mg kg-1 administered orally and daily for a one month period did not show any toxic effect in rats. This, coupled with the high LD50 value confirm that A. conyzoides is safe for use in ethnomedicine.
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How to cite this article:

A.C. Igboasoiyi, O.A. Eseyin , N.K. Ezenwa and H.O. Oladimeji , 2007. Studies on the Toxicity of Ageratum conyzoides. Journal of Pharmacology and Toxicology, 2: 743-747.

DOI: 10.3923/jpt.2007.743.747

URL: https://scialert.net/abstract/?doi=jpt.2007.743.747

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