Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 4 | Page No.: 330-339
DOI: 10.3923/jpt.2007.330.339
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effect of Calcitonin on Acute Hepatic Damage in Rats in vivo

Omar M.E. Abdel Salam, Amany A. Sleem and Nermeen M. Shaffie

Abstract:
This study aimed to investigate the effect of salmon calcitonin on the acute hepatic injury in rats. Hepatotoxicity was induced by CCl4 orally (2.8 mL kg-1 followed by 1.4 mL kg-1 after one week). Calcitonin at three dose levels (2.25, 4.5 or 9 mg kg-1, s.c.) or silymarin (25 mg kg-1, p.o.) was given daily for 14 days, starting at time of administration of CCl4. Liver damage was assessed by determining liver serum enzyme activities and by hepatic histopathology. Calcitonin administration decreased the elevations in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and also prevented the development of hepatic necrosis caused by CCl4. The effect of calcitonin was dose-dependent one. Calcitonin given to CCl4-treated rats at 2.25 mg kg-1 reduced the elevated plasma ALT by 25.5%. Calcitonin administered at doses of 4.5 or 9 mg kg-1 significantly decreased the raised plasma ALT by 49.3 and 72.4%, AST by 51.3 and 61%, ALP by 29.1 and 48.3%, respectively. Silymarin, in comparison, decreased elevated ALT, AST and ALP levels by 72.6, 67.4 and 64.4%, respectively Histopathologic examination of the livers of rats treated with CCl4 + calcitonin showed marked restoration of the normal architecture of the liver tissue. It is concluded that administration of calcitonin in liver injury induced by CCl4 results in less liver damage.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Omar M.E. Abdel Salam, Amany A. Sleem and Nermeen M. Shaffie, 2007. Effect of Calcitonin on Acute Hepatic Damage in Rats in vivo. Journal of Pharmacology and Toxicology, 2: 330-339.

DOI: 10.3923/jpt.2007.330.339

URL: https://scialert.net/abstract/?doi=jpt.2007.330.339

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom