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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 3 | Page No.: 264-270
DOI: 10.3923/jpt.2007.264.270
 
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Zinc oxide (ZnO): An Efficient Catalyst for the Synthesis of 4-arylmethylidene-2-phenyl 5(4H)-oxazolones Having Antimicrobial Activity

M.A. Pasha, V.P. Jayashankara, K.N. Venugopala and Gopal Krishna Rao

Abstract:
A straightforward and a general method has been developed for the synthesis of some important functionalized 4-arylmethylidene-2-phenyl-5(4H)-oxazolone derivatives by combining araldehydes and hippuric acid in the presence of catalytic amount of zinc oxide at room temperature in ethyl alcohol is reported. The method was very easy, rapid and products obtained were in excellent yields. The compounds were purified, characterized and were subjected for in vitro antibacterial activity (determination of Minimum Inhibitory Concentration (MIC) by micro titration method) using two standard drugs Streptomycin and Ampicillin against Bacillus subtilis and Escherichia coli. Five of the synthesized compounds showed remarkable antibacterial activity when compared to that of standards.
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How to cite this article:

M.A. Pasha, V.P. Jayashankara, K.N. Venugopala and Gopal Krishna Rao, 2007. Zinc oxide (ZnO): An Efficient Catalyst for the Synthesis of 4-arylmethylidene-2-phenyl 5(4H)-oxazolones Having Antimicrobial Activity. Journal of Pharmacology and Toxicology, 2: 264-270.

DOI: 10.3923/jpt.2007.264.270

URL: https://scialert.net/abstract/?doi=jpt.2007.264.270

COMMENTS
28 February, 2013
soujanya :
hai sir
this souji,
research scholar from padmavathi university AP,
Sir I tried OXAZOLONE synthesis with ur method, really it is good, very fast, yield is high, but i have one doubt
how zinc oxide is eliminated from the compound,
product is not extracted with cold alcohol and
what is the recrystallization solvent

I hope you understood my doubt, pls send me reply
Thank you sir
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