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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 2 | Page No.: 167-175
DOI: 10.3923/jpt.2006.167.175
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Antioxidant and Antimicrobial Properties of Telfairia occidentalis (Fluted pumpkin) Leaf Extracts

G. Oboh, E.E. Nwanna and C.A. Elusiyan

Dietary antioxidants are beneficial because of their protective roles against oxidative stress involved in the pathogenesis of multiple diseases such as cancer, anaemia, diabetics and cardiovascular diseases. This study sought to investigate the antioxidant and antimicrobial properties of ethanolic and aqueous extracts of Telfairia occidentalis, a popularly consumed green leafy vegetable in Nigeria. Telfairia occidentalis is popularly used in soup and folk medicine preparation in the management of various diseases such as diabetics, anaemia and gastrointestinal disorder. The result of this study revealed that both the ethanolic and aqueous extracts of Telfairia occidentalis leaves contain saponin, alkaloid and tannins, however, the aqueous extract had a significantly higher (p<0.05) total phenol (12.2%), reducing power (1.9 OD700) and free radical scavenging ability (92%) than the ethanolic extracts [total phenol (5.5%), reducing power (1.5 OD700), free radical scavenging ability (25%)]. Conversely, the ethanolic extract (0.5 mg mL-1) had a higher inhibitory effect on some of the commonly encountered Enterobacterioceae in Nigeria, namely Escherichia coli (4.0 mm), Pseudomonads aeruginosa (8.0 mm) and Proteus sp. (4.0 mm), except Salmonella typhii (2.0 mm) where the aqueous extracts had a higher inhibition of the growth. However, both extracts did not inhibit the growth of the fungi tested, which are Aspergillus flavus, Aspergillus fumigatum, Penicillum italicm, Geotrichum albidum. It could be inferred from the study that extracts from Telfairia occidentalis leaf could scavenge and prevent free radical production and same time have antimicrobial property; although the aqueous extract had a higher antioxidant property, while the ethanolic extract had a higher antimicrobial property.
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  •    Biokinetics and Phyto-toxicity of Pumpkin Leaves Extract on Human Erythrocytes, “An in vitro Study”
  •    Combined Administration of Telfairia occidentalis and Vernonia amygdalina Leaf Powders Ameliorates Garlic-induced Hepatotoxicity in Wistar Rats
  •    Some Medicinal Values of Telfairia occidentalis: A Review
How to cite this article:

G. Oboh, E.E. Nwanna and C.A. Elusiyan, 2006. Antioxidant and Antimicrobial Properties of Telfairia occidentalis (Fluted pumpkin) Leaf Extracts. Journal of Pharmacology and Toxicology, 1: 167-175.

DOI: 10.3923/jpt.2006.167.175






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