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Interactions of Cyclooxygenase Inhibitors with Reactive Oxygen Species |
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Sheikh A. Saeed,
Muhammad A. Mesaik,
J. Quadri,
S. Tasneem,
A. Motiwala,
U. Khalid,
Syed U. Ali,
Faisal Hussain and Muhammad I. Choudhary |
Abstract:
Reactive oxygen species (ROS) are a natural means of defense in the body produced mainly by phagocytic and mast cells. However, their overproduction plays an important role in the pathogenesis of numerous diseases, such as atherosclerosis, cancer, myocardial infarction (MI) and other chronic inflammatory diseases. This review attempts to present our understanding in the interaction of anti-inflammatory drugs with ROS. It has been proposed that in addition to inhibition of prostaglandin synthesis, the anti-inflammatory actions of non-steroidal anti-inflammatory drugs (NSAIDs) may also be due to their free radical scavenging effect. The action of NSAIDs has been demonstrated against an array of ROS, including O-2, OH-, HOCl, as well as various Reactive Nitrogen Species (RNS) such as nitric oxide (NO) and peroxynitrite (ONOO)-. NSAIDs are thought to compete with chloride for the active site of myeloperoxidase (MPO), thereby inhibiting HOCl strong oxidant radical production.
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How to cite this article:
Sheikh A. Saeed, Muhammad A. Mesaik, J. Quadri, S. Tasneem, A. Motiwala, U. Khalid, Syed U. Ali, Faisal Hussain and Muhammad I. Choudhary, 2006. Interactions of Cyclooxygenase Inhibitors with Reactive Oxygen Species. Journal of Pharmacology and Toxicology, 1: 115-125.
DOI: 10.3923/jpt.2006.115.125
URL: https://scialert.net/abstract/?doi=jpt.2006.115.125
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