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Journal of Pharmacy and Allied Health Sciences
  Year: 2014 | Volume: 4 | Issue: 1 | Page No.: 1-14
DOI: 10.3923/jpahs.2014.1.14
Modification of Crystallization Behaviour of Sertaconazole by Preparing its Solid Dispersions
A.K. Aggarwal and P. Jindal

Abstract:
Sertaconazole is one of the most effective fungicidal and fungistatic agents. But its practical use is limited due to its extremely low aqueous solubility and therefore, search for an adequate delivery system is still a challenging issue. So, the aim of present study was to modify the crystalline behaviour of sertaconazole by preparing its solid dispersions so as to increase the solubility of sertaconazole. Some methods have been reported in literature but these methods require high amount of carrier which can be toxic in such amount. In the present study, melting method was used to prepare the solid dispersions and these solid dispersions were characterized by various techniques in solid as well as in solution state. Solution state studies showed a profound increase in the solubility and dissolution rate of sertaconazole with nicotinamide in presence of surfactant and fatty acid and solid state studies showed an absence of chemical interaction between sertaconazole and nicotinamide. It is concluded that oleic acid and tween 80 when combined with sertaconazole and nicotinamide in the solid dispersions results in profound increase in solubility. So, these dispersions can be used for oral delivery of sertaconazole and can be considered as better choice for the treatment of dermatological and gynaecological infections.
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How to cite this article:

A.K. Aggarwal and P. Jindal , 2014. Modification of Crystallization Behaviour of Sertaconazole by Preparing its Solid Dispersions. Journal of Pharmacy and Allied Health Sciences, 4: 1-14.

DOI: 10.3923/jpahs.2014.1.14

URL: https://scialert.net/abstract/?doi=jpahs.2014.1.14

 
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