
	Journal of Pharmacy and Allied Health Sciences
	Year: 2011 \| Volume: 1 \| Issue: 2 \| Page No.: 49-57 DOI: 10.3923/jpahs.2011.49.57

Evaluation of Herbal Ointments Formulated with Methanolic Extract of Cajanus scarabaeoides

S. Pattanayak, S.S. Nayak, S.C. Dinda, D. Panda and K.P. Navale

Abstract: The plant Cajanus scarabaeoides (L.) possess wound healing, anti-diabetic, anti- inflammatory, hepatoprotective, anti-diarrhoeal, anthelmintic and anti-bacterial activities. The emulsifying ointment formulations containing extracts of the above mentioned herb were formulated, evaluated and their wound healing activity was studied on experimentally induced open wounds in albino rats. The extract (0.5 and 1.0. g) was incorporated into 10 g of a simple ointment base by melting and triturating to give two batches of each the both hydrophilic and hydrophobic ointment formulation. The pH, viscosity, spreadability, stability studies and skin irritation test were determined. The measurement of the wound areas were taken up-to 18th days and the percentages of wound closures were calculated. Blank ointment base and Gentamycin ointment (1% w/w) served as the control and standard treatments. The prepared ointments were passed all the physical evaluation parameters. There were no changes in pH, viscosity, spreadability, consistency, and phase separation when the ointments were kept at different temperatures for 90 days. These formulations did not produce any skin irritation .Topical application of the prepared ointment on the excision wound in rats caused a significantly (p<0.05) higher rate of wound healing and reduced the epithelialization period in a dose-related manner. Application of the hydrophilic ointment containing the highest concentrations of Cajanus scarabaeoides (L.) extract (1, 10 g ointment) showed the highest rate of wound closure . The formulated ointments were evaluated and effective in wound care and should be explored in harnessing the potentials of the plant in the treatment of topical diseases.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Formulation and Evaluation of Hydrophilic Ointments Containing Dry Methanolic Extract of Acacia nilotica Pods

•	Preliminary Study on Polysaccharides and Certain Secondary Metabolites of Medicinal Plants used in Cote D’Ivoire for Wound Healing

•	Role of Medicinal Plants in Wound Healing

•	Effects of Strobilanthes crispus Juice on Wound Healing and Antioxidant Enzymes in Normal and Streptozotocin-Induced Diabetic Rats

•	Natural Cumin Seeds for Wound Healing Activity in Albino Rats

•	Wound Healing Activity of Memecylon umbellatum Burm

How to cite this article:

S. Pattanayak, S.S. Nayak, S.C. Dinda, D. Panda and K.P. Navale, 2011. Evaluation of Herbal Ointments Formulated with Methanolic Extract of Cajanus scarabaeoides. Journal of Pharmacy and Allied Health Sciences, 1: 49-57.

DOI: 10.3923/jpahs.2011.49.57

URL: https://scialert.net/abstract/?doi=jpahs.2011.49.57

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library

Science Alert