Evaluation of Herbal Ointments Formulated with Methanolic Extract of Cajanus scarabaeoides

Research Article

Evaluation of Herbal Ointments Formulated with Methanolic Extract of Cajanus scarabaeoides

S. Pattanayak, S.S. Nayak, S.C. Dinda, D. Panda and K.P. Navale

The plant Cajanus scarabaeoides (L.) possess wound healing, anti-diabetic, anti- inflammatory, hepatoprotective, anti-diarrhoeal, anthelmintic and anti-bacterial activities. The emulsifying ointment formulations containing extracts of the above mentioned herb were formulated, evaluated and their wound healing activity was studied on experimentally induced open wounds in albino rats. The extract (0.5 and 1.0. g) was incorporated into 10 g of a simple ointment base by melting and triturating to give two batches of each the both hydrophilic and hydrophobic ointment formulation. The pH, viscosity, spreadability, stability studies and skin irritation test were determined. The measurement of the wound areas were taken up-to 18th days and the percentages of wound closures were calculated. Blank ointment base and Gentamycin ointment (1% w/w) served as the control and standard treatments. The prepared ointments were passed all the physical evaluation parameters. There were no changes in pH, viscosity, spreadability, consistency, and phase separation when the ointments were kept at different temperatures for 90 days. These formulations did not produce any skin irritation .Topical application of the prepared ointment on the excision wound in rats caused a significantly (p<0.05) higher rate of wound healing and reduced the epithelialization period in a dose-related manner. Application of the hydrophilic ointment containing the highest concentrations of Cajanus scarabaeoides (L.) extract (1, 10 g ointment) showed the highest rate of wound closure . The formulated ointments were evaluated and effective in wound care and should be explored in harnessing the potentials of the plant in the treatment of topical diseases.

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S. Pattanayak, S.S. Nayak, S.C. Dinda, D. Panda and K.P. Navale, 2011. Evaluation of Herbal Ointments Formulated with Methanolic Extract of Cajanus scarabaeoides. Journal of Pharmacy and Allied Health Sciences, 1: 49-57.

DOI: 10.3923/jpahs.2011.49.57

URL: https://scialert.net/abstract/?doi=jpahs.2011.49.57

Journal of Pharmacy and Allied Health Sciences

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Authors

S. Pattanayak

S.S. Nayak

S.C. Dinda

D. Panda

K.P. Navale

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Research Article

Evaluation of Herbal Ointments Formulated with Methanolic Extract of Cajanus scarabaeoides

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