Some Variables Affecting the Formulation of Ketoprofen Sustained Release Oral Tablet using Polyelectrolyte Complex as a Matrix Former

Research Article

Some Variables Affecting the Formulation of Ketoprofen Sustained Release Oral Tablet using Polyelectrolyte Complex as a Matrix Former

M.H. Sabar, L.H. Samein and Hayder B. Sahib

Ketoprofen is a non-steroidal anti-inflammatory drug used in the treatment of many diseases including rheumatoid arthritis. This investigation concerned with preparation of ketoprofen as a sustained release oral tablet using Polyelectrolyte Complex (PEC) that Composed of Chitosan (CS) as Cationic Polymer and carbopol (CP) as anionic polymer. Polyelectrolyte complex were formed by electrostatic interaction between the carboxyl group of CP and amine group of CS at pH5. (FT-IR) spectra of the complex were analyzed. Different factors affecting the swelling index and release rate were studied. The results showed that CS: CP prepared in the ratio of (1:4) had highest swelling index and release rate. Also changing the molecular weight of CS from medium (CS_m) to high molecular weight (CS_h), no significant difference observed in the dissolution profile. In addition it was seen that retardation in the release would occur as the solution of CS acetic acid was cooled to 8EC and with increasing the amount of PEC powder in formula. In conclusion the study showed retardation in the release rate with increase in the strength of PEC. Moreover, the increase in the amount of CP showed PH dependant release.

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M.H. Sabar, L.H. Samein and Hayder B. Sahib, 2011. Some Variables Affecting the Formulation of Ketoprofen Sustained Release Oral Tablet using Polyelectrolyte Complex as a Matrix Former. Journal of Pharmacy and Allied Health Sciences, 1: 1-15.

DOI: 10.3923/jpahs.2011.1.15

URL: https://scialert.net/abstract/?doi=jpahs.2011.1.15

Journal of Pharmacy and Allied Health Sciences

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Authors

M.H. Sabar

L.H. Samein

Hayder B. Sahib

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Research Article

Some Variables Affecting the Formulation of Ketoprofen Sustained Release Oral Tablet using Polyelectrolyte Complex as a Matrix Former

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