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Journal of Medical Sciences
  Year: 2020 | Volume: 20 | Issue: 1 | Page No.: 24-28
DOI: 10.3923/jms.2020.24.28
 
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Reduced Birth Weight in Early-onset Preeclampsia Might Potentially Be Due to Placental Glucose Transporters Disorders
Adhi Pribadi , Johanes Cornelius Mose, Tri Hanggono Achmad and Anita Deborah Anwar

Abstract:
Background and Objective: Glucose transport play an important role on fetal growth so that if this process disrupted could be stunted growth of the fetus. Preeclampsia was a pathological state so that increase risk incidence of stunted fetal growth. This study aims to investigate impaired glucose transport in preeclampsia. Materials and Methods: Samples were taken from 58 placental tissues after birth, divided into 2 groups by consecutive sampling. Samples sent to the Clinical Pathology laboratory then stored in a temperature of -80°C. The samples were ground and resuspended in phosphate buffer saline, subjected to an ELISA method to placental growth factor (PlGF), glucose transporter 1(GLUT1) and glucose transporter 3(GLUT3) analyzed. Chart of Lubchenko was used to further categorize infant birth weight. Results: Proportion of SGA samples in the early onset preeclampsia (EOP) group (44.8%) was significantly higher than late onset preeclampsia (LOP) (10.3%) group. PlGF levels for the SGA group was significantly lower than that in Non-SGA in EOP. GLUT1 and GLUT3 levels were also lower in the SGA group than in non-SGA. There were also significant differences in birth weight between the SGA with non-SGA samples. Moreover, PlGF, GLUT1 and GLUT3 showed a significant correlation with the birth weight in the EOP group, but not in LOP. Conclusion: The number of SGA incidents in the EOP group was higher than LOP group. Low birth weight in EOP have correlation with reduced of PLGF, GLUT1 and GLUT3.
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How to cite this article:

Adhi Pribadi, Johanes Cornelius Mose, Tri Hanggono Achmad and Anita Deborah Anwar, 2020. Reduced Birth Weight in Early-onset Preeclampsia Might Potentially Be Due to Placental Glucose Transporters Disorders. Journal of Medical Sciences, 20: 24-28.

DOI: 10.3923/jms.2020.24.28

URL: https://scialert.net/abstract/?doi=jms.2020.24.28

 
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