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Journal of Medical Sciences

Year: 2014 | Volume: 14 | Issue: 6-8 | Page No.: 290-296
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Authors

Sanad Fouad Abdou

Mostafa Al- Wakeel

Mahmoud Helmy El- Saied

Keywords

Research Article

Protective Effect of Silymarin and Vitamine-E in Hepatotoxicity Induced by Valporic Acid in Albino Rats

Sanad Fouad Abdou, Mostafa Al- Wakeel and Mahmoud Helmy El- Saied
Administration of valporic acid, the most common medication prescribed against epilepsy produces many metabolic and morphological aberrations in liver due to the fact that liver is the main detoxifying site for these antiepileptic drugs. This experimental work was done for study of the prophylactic role of silymarin and vitamin E in hepatotoxic induced by valporic acid in albino rats. Fifty adult male albino rats weighting 150-200 g were divided into five equal groups, one control and the other four for the drugs. Group I control group is subdivided into two subgroups (IA, IB). Group II ingested valporic acid, group III ingested valporic acid+silymarin, group IV ingested valporic acid+vitamine E and finally group V ingested valporic acid+both drugs, the ingestion was done through orogastric tube for four week. After four weeks biochemical studies (ALT, AST and total bilirubin) were done for all rats in all groups, then the rats were sacrificed and histopathological studies were done for their livers. Biochemical analysis revealed significant increased in AST, ALT and total bilirubin in the group II, III, IV and V in comparison with control groups and revealed significant decrease in the group III, IV and V in comparison with group II. Histopathological examination of the group II revealed necro-inflammatory foci with infiltration of the hepatic lobules with inflammatory cells and inflammation in the portal tract. Histopathological examination of the liver section of group III, IV and V showed mild necrosis and inflammation in hepatic lobules and showed mild inflammation in the portal tract. The liver is highly affected by ingestion of valporic acid. However, ingestion of silymarin and/or vitamine E that is naturally occurring antioxidants can decrease this harmful effect of these drugs on the liver. Therefore, the patient on chronic use of valporic acid must use silymarin and/or vitamin E to protect their livers.
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